Estimated pill intake with on-demand PrEP with oral TDF/FTC using TFV-DP concentration in dried blood spots in the ANRS IPERGAY trial,Journal of Antimicrobial Chemotherapy

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Estimated pill intake with on-demand PrEP with oral TDF/FTC using TFV-DP concentration in dried blood spots in the ANRS IPERGAY trial
Journal of Antimicrobial Chemotherapy ( IF 5.2 ) Pub Date : 2021-07-19 , DOI: 10.1093/jac/dkab253
Lauriane Goldwirt ₁ , Rebecca Bauer ₂ , Geoffroy Liegeon ₃ , Isabelle Charreau ₂ , Constance Delaugerre ₄ , Laurent Cotte ₅ , Gilles Pialou ₆ , Eric Cua ₇ , Aïcha Laghzal ₁ , Lane Buschman ₈ , Peter L Anderson ₈ , Samia Mourah ₁ , Laurence Meyer ₉ , Jean-Michel Molina ₃ ,

Affiliation

Assistance Publique des Hôpitaux de Paris, Saint-Louis Hospital, Department of Pharmacology, Université de Paris Diderot (Paris 7), INSERM UMRS976, France.
Inserm SC10, Villejuif, France.
Assistance Publique des Hôpitaux de Paris, Saint-Louis Hospital, Department of Infectious Diseases, Université de Paris Diderot (Paris 7), INSERM U941, Paris, France.
Assistance Publique des Hôpitaux de Paris, Saint-Louis Hospital, Department of Virology, Université de Paris Diderot (Paris 7), INSERM U944, France.
Hospices Civils de Lyon, Croix-Rousse Hospital, Department of Infectious Diseases, INSERM U1052, Lyon, France.
Assistance Publique des Hôpitaux de Paris, Tenon Hospital, Department of Infectious Diseases, Sorbonne Université, UPMC Université, (Paris 6), France.
Hôpital de l'Archet, Department of Infectious Diseases, Nice University Hospital, France.
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Assistance Publique des Hôpitaux de Paris, Bicêtre Hospital, Université Paris-Saclay, UVSQ, Inserm, Le Kremlin-Bicêtre, France.

Tenofovir diphosphate (TFV-DP) concentration in dried blood spots (DBSs) is a reliable pharmacokinetics biomarker of adherence to tenofovir disoproxil fumarate (TDF). We aimed to use DBSs to estimate pill intake among participants using on-demand pre-exposure prophylaxis (PrEP) and to identify predictive factors associated with higher TFV-DP concentrations.

中文翻译：

在 ANRS IPERGAY 试验中使用干血斑中的 TFV-DP 浓度，使用口服 TDF/FTC 的按需 PrEP 估计药丸摄入量

干血斑 (DBS) 中的替诺福韦二磷酸 (TFV-DP) 浓度是富马酸替诺福韦二吡呋酯 (TDF) 依从性的可靠药代动力学生物标志物。我们旨在使用 DBS 估计使用按需暴露前预防 (PrEP) 的参与者的药丸摄入量，并确定与较高 TFV-DP 浓度相关的预测因素。

更新日期：2021-09-19

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