Recent studies invoke phase separation as a mechanism underlying the formation of ‘transcriptional condensates’. However, similarities between transcriptional condensates and the previously introduced ‘transcription factories’ model raise the question of what distinguishes the two models. One crucial aspect to consider is the contribution of intrinsically disordered regions in transcription-relevant factors. Rippe and Papantonis suggest that intrinsically disordered regions in transcription-relevant factors underlie the formation of both ‘transcriptional condensates’ and ‘transcription factories’.

中文翻译：

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RNA 聚合酶 II 转录区室：从多价染色质结合到液滴形成？

最近的研究将相分离作为“转录凝聚物”形成的一种机制。然而，转录浓缩物与之前引入的“转录工厂”模型之间的相似性引发了两个模型的区别问题。需要考虑的一个关键方面是内在无序区域在转录相关因子中的贡献。Rippe 和 Papantonis 认为，转录相关因子中固有的无序区域是“转录凝聚物”和“转录工厂”形成的基础。