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Functional Connectivity during Encoding Predicts Individual Differences in Long-Term Memory
Journal of Cognitive Neuroscience ( IF 3.2 ) Pub Date : 2021-10-01 , DOI: 10.1162/jocn_a_01759
Qi Lin 1 , Kwangsun Yoo 1 , Xilin Shen 2 , Todd R Constable 1, 2 , Marvin M Chun 1, 2
Affiliation  

What is the neural basis of individual differences in the ability to hold information in long-term memory (LTM)? Here, we first characterize two whole-brain functional connectivity networks based on fMRI data acquired during an n-back task that robustly predict individual differences in two important forms of LTM, recognition and recollection. We then focus on the recognition memory model and contrast it with a working memory model. Although functional connectivity during the n-back task also predicts working memory performance and the two networks have some shared components, they are also largely distinct from each other: The recognition memory model performance remains robust when we control for working memory, and vice versa. Functional connectivity only within regions traditionally associated with LTM formation, such as the medial temporal lobe and those that show univariate subsequent memory effect, have little predictive power for both forms of LTM. Interestingly, the interactions between these regions and other brain regions play a more substantial role in predicting recollection memory than recognition memory. These results demonstrate that individual differences in LTM are dependent on the configuration of a whole-brain functional network including but not limited to regions associated with LTM during encoding and that such a network is separable from what supports the retention of information in working memory.



中文翻译:

编码过程中的功能连接预测长期记忆中的个体差异

在长期记忆 (LTM) 中保存信息的能力存在个体差异的神经基础是什么?在这里,我们首先基于在n- back 任务期间获得的 fMRI 数据来表征两个全脑功能连接网络,该数据可以稳健地预测 LTM 的两种重要形式(识别和回忆)中的个体差异。然后我们专注于识别记忆模型并将其与工作记忆模型进行对比。虽然在n期间的功能连接-back 任务还可以预测工作记忆性能,并且两个网络有一些共享的组件,它们也有很大的不同:当我们控制工作记忆时,识别记忆模型的性能保持稳健,反之亦然。仅在传统上与 LTM 形成相关的区域内的功能连接,例如内侧颞叶和显示单变量后续记忆效应的区域,对两种形式的 LTM 几乎没有预测能力。有趣的是,这些区域和其他大脑区域之间的相互作用在预测回忆记忆方面比识别记忆发挥更重要的作用。

更新日期:2021-10-08
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