Momordica. charantia is popularly used as a medicinal herb in ethnomedicine for the management of cardiovascular diseases. In this study, we evaluated the beneficial effects of the ethanolic extract of M. charantia (Linn.) in experimentally induced cardiovascular disorders using cholesterol-fed Wistar rat. Seventy-two experimental rats were randomly assigned into nine 9 groups of 8 rats each and treated as follows: Rats in group A (control) were given distilled water only; Rats in group B were given 30 mg/kg of cholesterol dissolved in coco-nut oil (cholesterol solution); Rats in group C were given cholesterol solution and 100 mg/kg Atorvastatin; Rats in group D were given 250 mg/kg of M. charantia and cholesterol solution; Rats in group E were given 500 mg/kg of M. charantia and cholesterol solution; Rats in group F were given 250 mg/kg. M. charantia; Rats in group G were given 500 mg/kg M. charantia; Rats in group H were given 1 ml of coconut oil; Rats in group I were given 100 mg/kg of Atorvastatin. Mean LDL-cholesterol was significantly (P < 0.05) lower in groups F, E and H as compared with the control groups. Histological analysis of the heart and aortic branch of the experimental rats show that cholesterol administration induced myocardial degeneration, vascular ulceration and stenosis in the aorta and heavy perivascular infiltrates of inflammatory cells. However, these deleterious effects were ameliorated upon treatment with Momordica charantia and Atorvastatin as compared with the control groups. Our findings indicate the possible cardiovascular benefits of M. charantia.

中文翻译：

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苦瓜对胆固醇喂养的 Wistar 大鼠的心血管益处

苦瓜。苦瓜在民族医学中被广泛用作治疗心血管疾病的药草。在这项研究中，我们评估了苦瓜 (Linn.) 乙醇提取物在使用胆固醇喂养的 Wistar 大鼠实验性诱发的心血管疾病中的有益作用。72只实验大鼠随机分为9组，每组8只，处理如下：A组（对照组）仅给予蒸馏水；B组给予30mg/kg的胆固醇溶解于椰子油中（胆固醇溶液）；C组给予胆固醇溶液和阿托伐他汀100 mg/kg；D组大鼠给予苦瓜250 mg/kg和胆固醇溶液；E组大鼠给予苦瓜500mg/kg胆固醇溶液；F组大鼠给予250mg/kg。M。苦参; G组大鼠给予苦瓜500 mg/kg；H组大鼠给予1毫升椰子油；I组的大鼠被给予100mg/kg的阿托伐他汀。与对照组相比，F、E 和 H 组的平均低密度脂蛋白胆固醇显着降低（P < 0.05）。对实验大鼠心脏和主动脉分支的组织学分析表明，给予胆固醇诱导主动脉中的心肌变性、血管溃疡和狭窄以及炎症细胞的大量血管周围浸润。然而，与对照组相比，苦瓜和阿托伐他汀治疗后这些有害作用得到改善。我们的研究结果表明苦瓜可能对心血管有益。I组的大鼠被给予100mg/kg的阿托伐他汀。与对照组相比，F、E 和 H 组的平均低密度脂蛋白胆固醇显着降低（P < 0.05）。对实验大鼠心脏和主动脉分支的组织学分析表明，给予胆固醇诱导主动脉中的心肌变性、血管溃疡和狭窄以及炎症细胞的大量血管周围浸润。然而，与对照组相比，苦瓜和阿托伐他汀治疗后这些有害作用得到改善。我们的研究结果表明苦瓜可能对心血管有益。I组的大鼠被给予100mg/kg的阿托伐他汀。与对照组相比，F、E 和 H 组的平均低密度脂蛋白胆固醇显着降低（P < 0.05）。对实验大鼠心脏和主动脉分支的组织学分析表明，给予胆固醇诱导主动脉中的心肌变性、血管溃疡和狭窄以及炎症细胞的大量血管周围浸润。然而，与对照组相比，苦瓜和阿托伐他汀治疗后这些有害作用得到改善。我们的研究结果表明苦瓜可能对心血管有益。对实验大鼠心脏和主动脉分支的组织学分析表明，给予胆固醇诱导主动脉中的心肌变性、血管溃疡和狭窄以及炎症细胞的大量血管周围浸润。然而，与对照组相比，苦瓜和阿托伐他汀治疗后这些有害作用得到改善。我们的研究结果表明苦瓜可能对心血管有益。对实验大鼠心脏和主动脉分支的组织学分析表明，胆固醇给药诱导了主动脉中的心肌变性、血管溃疡和狭窄以及炎症细胞的大量血管周围浸润。然而，与对照组相比，苦瓜和阿托伐他汀治疗后这些有害作用得到改善。我们的研究结果表明苦瓜可能对心血管有益。