Epigenetic abnormalities play a crucial role in many tumors, including glioma. RNA methylation occurs as an epigenetic modification similar to DNA methylation and histone modification. m6A methylation is the most common and most intensively studied RNA methylation, which can be found throughout the RNA life cycle and exert biological functions by affecting RNA metabolism. The m6A modification is primarily associated with three types of protease, which are encoded by the writer, eraser and reader genes, respectively. It has been shown that the m6A methylation has close connections with the occurrence and development of many tumors, including glioma. In this study, the concept and the research progress of m6A methylation are reviewed, especially the role of m6A methylation in glioma. Moreover, we will discuss how glioma is paving the way to the development of new therapeutic options based on the inhibition of m6A deposition.

中文翻译：

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m6A RNA甲基化在中枢神经系统发育和胶质瘤发病机制中的作用

表观遗传异常在包括神经胶质瘤在内的许多肿瘤中起着至关重要的作用。RNA 甲基化作为类似于 DNA 甲基化和组蛋白修饰的表观遗传修饰发生。m6A甲基化是最常见和研究最深入的RNA甲基化，可以在整个RNA生命周期中发现，并通过影响RNA代谢发挥生物学功能。m6A 修饰主要与三种类型的蛋白酶相关，它们分别由 writer、eraser 和 reader 基因编码。研究表明，m6A甲基化与包括胶质瘤在内的多种肿瘤的发生发展密切相关。本研究综述了m6A甲基化的概念和研究进展，特别是m6A甲基化在胶质瘤中的作用。而且，