This retrospective cohort study assessed the annualized incidence rate (IR) of acute pancreatitis (AP) in a nationally representative US adult population, as well as the variation in the risk of AP events across strata of triglyceride (TG) levels. Data were obtained from IQVIA’s US Ambulatory Electronic Medical Records (EMR) database linked with its LRxDx Open Claims database. Inclusion criteria included ≥1 serum TG value during the overlapping study period of the EMR and claims databases, ≥1 claim in the 12-month baseline period, and ≥ 1 claim in the 12 months post index. All TG measurements were assigned to the highest category reached: < 2.26, ≥2.26 to ≤5.65, > 5.65 to ≤9.94, > 9.94, and > 11.29 mmol/L (< 200, ≥200 to ≤500, > 500 to ≤880, > 880, and > 1000 mg/dL, respectively). The outcome of interest was AP, defined as a hospitalization event with AP as the principal diagnosis. In total, 7,119,195 patients met the inclusion/exclusion criteria, of whom 4158 (0.058%) had ≥1 AP events in the prior 12 months. Most patients (83%) had TGs < 2.26 mmol/L (< 200 mg/dL), while < 1% had TGs > 9.94 mmol/L (> 880 mg/dL). Overall, the IR of AP was low (0.08%; 95% confidence internal [CI], 0.08–0.08%), but increased with increasing TGs (0.08% in TGs < 2.26 mmol/L [< 200 mg/dL] to 1.21% in TGs > 11.29 mmol/L [> 1000 mg/dL]). In patients with a prior history of AP, the IR of AP increased dramatically; patients with ≥2 AP events at baseline had an IR of 29.98% (95% CI, 25.1–34.9%). The risk of AP increases with increasing TG strata; however, the risk increases dramatically among patients with a recent history of AP.

中文翻译：

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甘油三酯水平与初始和复发急性胰腺炎发病率的相关性

这项回顾性队列研究评估了具有全国代表性的美国成年人群中急性胰腺炎 (AP) 的年发生率 (IR)，以及跨甘油三酯 (TG) 水平层级的 AP 事件风险变化。数据来自 IQVIA 的美国流动电子病历 (EMR) 数据库，该数据库与其 LRxDx Open Claims 数据库相关联。纳入标准包括在 EMR 和索赔数据库的重叠研究期间≥1 次血清 TG 值、在 12 个月基线期≥1 次索赔以及在指数后 12 个月内≥1 次索赔。所有 TG 测量值都被分配到达到的最高类别：< 2.26，≥2.26 至 ≤5.65，> 5.65 至 ≤9.94，> 9.94 和 > 11.29 mmol/L（< 200，≥200 至 ≤500，> 500 至 ≤880 、 > 880 和 > 1000 mg/dL）。感兴趣的结果是 AP，定义为以 AP 为主要诊断的住院事件。总共有 7,119,195 名患者符合纳入/排除标准，其中 4158 名（0.058%）在过去 12 个月内发生了≥1 次 AP 事件。大多数患者 (83%) TGs < 2.26 mmol/L (< 200 mg/dL)，而 < 1% TGs > 9.94 mmol/L (> 880 mg/dL)。总体而言，AP 的 IR 较低（0.08%；95% 置信内部 [CI]，0.08-0.08%），但随着 TG 的增加而增加（TG < 2.26 mmol/L [< 200 mg/dL] 至 1.21 的 0.08% TG 中的百分比 > 11.29 mmol/L [> 1000 mg/dL]）。在既往有 AP 病史的患者中，AP 的 IR 显着增加；基线时发生≥2 次 AP 事件的患者的 IR 为 29.98%（95% CI，25.1-34.9%）。AP的风险随着TG层数的增加而增加；然而，近期有 AP 病史的患者风险显着增加。