Nanocarriers, such as liposomes and micelles, were developed to enhance the delivery of therapeutic drugs to malignant tissues. Internal or external stimuli can be applied to achieve spatiotemporal controlled release from these carriers. This will result in enhancing their therapeutic efficacy while reducing toxicity. Mathematical modeling is used to simulate drug release from nanocarriers; this will facilitate and optimize the development and design of desirable nanocarriers in a systematic manner, rather than a trial-and-error approach. This review summarizes nine mathematical models often used to simulate drug release from nanocarriers and reviews studies which employed these models to simulate drug release from conventional as well as temperature-, pH-, and ultrasound-triggered micelles and liposomes.

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脂质体和胶束抗癌药物释放动力学建模：综述

纳米载体，如脂质体和胶束，被开发用于增强治疗药物向恶性组织的递送。可以应用内部或外部刺激来实现这些载体的时空受控释放。这将导致增强它们的治疗功效，同时降低毒性。数学模型用于模拟纳米载体的药物释放；这将以系统的方式促进和优化理想纳米载体的开发和设计，而不是反复试验的方法。本综述总结了常用于模拟从纳米载体释放药物的九个数学模型，并回顾了使用这些模型来模拟从常规以及温度、pH 和超声触发的胶束和脂质体释放药物的研究。