An integrated in vitro in silico approach was employed to investigate albuterol administration to an adult lung airway. Particle size characterization of aerosolized albuterol generated by a jet- and vibrating mesh nebulizer was evaluated in vitro using an adult ventilator circuit that consisted of an endotracheal tube (ETT) connected to a cooled Next Generation Impactor. The aerosol particle size distribution sampled by spectrophotometry was used to predict particle deposition in an in silico patient-specific seven-generation airway model using computational fluid dynamics (CFD). A Lagrangian particle tracking algorithm was used to investigate the effect of nebulizer type and position on drug delivery and compare the efficacy of drug administration through endotracheal intubation and oral route. A vibrating mesh nebulizer produced a larger lung dose than the jet nebulizer, with the aerosol characteristics being dependent on the location of the nebulizer in the ventilator circuit. The CFD analysis showed that the vibrating mesh nebulizer placed at the ventilator had a lower global and local deposition fraction down to the 7th airway generation with higher penetration beyond. Besides, delivery through the ETT was more efficient than oral delivery for the studied conditions. Particle deposition patterns in the various lung lobes were evaluated. Placement of the nebulizer in an adult ventilator circuit could target different areas of the lung.

采用集成的体外计算机模拟方法来研究沙丁胺醇对成人肺气道的给药。使用由连接到冷却的下一代撞击器的气管内导管 (ETT) 组成的成人呼吸机回路，在体外评估了由喷射和振动网状雾化器产生的雾化沙丁胺醇的粒径特征。通过分光光度法采样的气溶胶粒度分布用于预测计算机中的粒子沉积使用计算流体动力学 (CFD) 的患者特异性七代气道模型。使用拉格朗日粒子追踪算法研究雾化器类型和位置对给药的影响，并比较气管插管和口服给药的效果。振动网状雾化器比喷射雾化器产生更大的肺剂量，气溶胶特性取决于雾化器在呼吸机回路中的位置。CFD 分析表明，放置在呼吸机上的振动网状雾化器具有较低的全局和局部沉积率，直到第 7 代气道，渗透率更高。此外，对于所研究的条件，通过 ETT 递送比口服递送更有效。评估了不同肺叶中的颗粒沉积模式。将雾化器放置在成人呼吸机回路中可以针对肺部的不同区域。