Objective

Children are often sedated for renal blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) and may require low-dose oxygen administration. It is unclear whether low-dose oxygen administration affects results of BOLD MRI. We investigated the effect of low-dose oxygen administration on renal BOLD MRI and its variation by the presence or absence of renal disease.

Materials and methods

We retrospectively examined children undergoing MRI for renal disease between 2013 and 2020. Patients were divided into glomerulonephritis and non-glomerulonephritis groups; spin relaxation time (T2*) was determined using a 3.0 T MRI system.

Results

The study included 10 children (5 patients in each group); patient characteristics between the groups did not differ significantly. In the entire cohort, oxygen administration reduced mean spin relaxation rate (R2*) value in the medulla (p < 0.04). The mean R2* value decreased with oxygen administration in the non-glomerulonephritis group, whereas this was not observed in the glomerulonephritis group. The responses to oxygen administration of the two groups differed significantly in the cortex (p < 0.05) and medulla (p < 0.02).

Discussion

Low-dose oxygen administration affects the results of BOLD MRI. We suggest that understanding the fluctuations due to oxygen administration is useful in monitoring the disease activity of glomerulonephritis.

中文翻译：

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小剂量吸氧对肾小球肾炎患儿肾血氧合水平依赖性MRI的影响

客观的

儿童通常会因肾血氧合水平依赖性 (BOLD) 磁共振成像 (MRI) 而被镇静，并且可能需要低剂量给氧。目前尚不清楚低剂量吸氧是否会影响 BOLD MRI 的结果。我们研究了低剂量氧气给药对肾脏 BOLD MRI 的影响及其因是否存在肾脏疾病而导致的变化。

材料和方法

我们回顾性检查了 2013 年至 2020 年期间因肾病接受 MRI 的儿童。患者分为肾小球肾炎组和非肾小球肾炎组；自旋弛豫时间 (T2*) 使用 3.0 T MRI 系统确定。

结果

该研究包括 10 名儿童（每组 5 名患者）；组间患者特征无显着差异。在整个队列中，氧气管理降低了髓质的平均自旋弛豫率 (R2*) 值 ( p  < 0.04)。在非肾小球肾炎组中，平均 R2* 值随着吸氧而降低，而在肾小球肾炎组中未观察到这种情况。两组对氧气给药的反应在皮质（p  < 0.05）和髓质（p  < 0.02）中存在显着差异。

讨论

低剂量吸氧会影响 BOLD MRI 的结果。我们建议了解因吸氧引起的波动有助于监测肾小球肾炎的疾病活动。