ABSTRACT

Introduction

The use of blood derivatives and especially Plasma rich in growth factors (PRGF), for regenerative purposes has been a common trend along the last decades in the field of oral surgery, dermatology, orthopedics, and more recently in ophthalmology.

Areas covered

PRGF is a type of platelet-rich plasma that is being explored for the treatment of ocular injuries. The present review article highlights 50 ophthalmology-related publications about the application of PRGF in the treatment of acute and chronic pathologies in ophthalmology as well as most relevant challenges and future prospects.

Expert opinion

PRGF technology provides a wide range of formulations that can be used therapeutically in many different acute and chronic ocular pathologies. In addition to eye drops enriched with autologous growth factors, PRGF enables the preparation of both immunologically safe and fibrin-based formulations. Recent advances in the field have promoted PRGF storage for 12 months under freezing conditions, its daily use for 7 days at room temperature and the freeze-dried formulation. The thermally treated immunosafe formulation has shown promising clinical results for the treatment of several diseases such as Sjögren syndrome, graft versus host disease or cicatrizing conjunctivitis. In addition, several fibrin formulations have been preclinically evaluated and clinically incorporated as an adjuvant to ocular surface or glaucoma surgeries, dermal fat graft procedures, limbal stem cell expansion and retinal surgeries. The present review explores the latest scientific and clinical data, current challenges, and main prospects of this technology for the treatment of several ocular injuries.

中文翻译：

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富含生长因子的血浆在眼科中的应用进展：从眼表到眼底

摘要

介绍

在过去的几十年里，在口腔外科、皮肤科、骨科以及最近的眼科领域，将血液衍生物，尤其是富含生长因子 (PRGF) 的血浆用于再生目的已成为一种普遍趋势。

涵盖的领域

PRGF 是一种富含血小板的血浆，正在探索用于治疗眼部损伤。本综述文章重点介绍了 50 篇关于 PRGF 在眼科急慢性病理治疗中的应用以及最相关的挑战和未来前景的眼科相关出版物。

专家意见

PRGF 技术提供了广泛的配方，可用于治疗许多不同的急性和慢性眼部疾病。除了富含自体生长因子的滴眼液外，PRGF 还能够制备免疫安全和基于纤维蛋白的制剂。该领域的最新进展促进了 PRGF 在冷冻条件下储存 12 个月、在室温下每天使用 7 天和冻干配方。经热处理的免疫安全配方已显示出治疗多种疾病的有希望的临床结果，例如干燥综合征、移植物抗宿主病或瘢痕性结膜炎。此外，几种纤维蛋白制剂已经过临床前评估并在临床上用作眼表或青光眼手术的佐剂，真皮脂肪移植手术、角膜缘干细胞扩增和视网膜手术。本综述探讨了该技术治疗几种眼部损伤的最新科学和临床数据、当前挑战和主要前景。