Abstract

Purpose

The aim of our study was to acquire non-invasive data from coronary flow velocity profiles during exercise in groups of healthy subjects and of patients with arterial hypertension.

Material and Methods

We enrolled 83 patients into two groups: (1) 35 non-selected consecutive healthy subjects; (2) 25 consecutive patients with arterial hypertension. All the patients performed supine bicycle symptoms-limited tests. Throughout exercise the diastolic peaks of coronary flow velocity in LAD were recorded. Coronary flow velocity reserve (CFVR) was calculated off-line. Profiles of coronary artery velocity were acquired for all groups. The coronary artery flow parameters investigated were comparable in healthy and hypertensive patients at every stage.

Results

The average diastolic velocities were 54.8 ± 12.9 vs. 51.8 ± 12.2 cm/s, at 50 W; 69.2 ± 17.1 vs 64.4 ± 19.1 cm/s at 75 W; 70.7 ± 16.4 vs. 76.1 ± 19.0 cm/s at 100 W; 80.0 ± 16.0 vs. 72.9 ± 16.1 cm/s at 125 W; 83.7 ± 12.2 vs. 81.4 ± 17.0 at 150 W, p- non-significant, respectively. On average, the healthy group reached CFVR > 2.0 at a heart rate of 110–120 beats/min at 75 W. During supine bicycle exercise, healthy subjects and patients with arterial hypertension have a similar coronary artery flow velocity profile.

Conclusion

The routine exercise echocardiography test can feasibly be supplemented with the additional measurement of coronary flow velocity during routine supine exercise stress tests, as the normal range of CFVR is reached before submaximal heart rate.

中文翻译：

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运动超声心动图冠状动脉血流动力学

摘要

目的

我们研究的目的是从健康受试者和动脉高血压患者组运动期间的冠状动脉血流速度曲线中获取非侵入性数据。

材料与方法

我们将 83 名患者分为两组：（1）35 名未选择的连续健康受试者；(2)连续25例动脉高血压患者。所有患者都进行了仰卧自行车症状限制测试。在整个运动过程中，记录了 LAD 中冠状动脉血流速度的舒张期峰值。离线计算冠状动脉血流速度储备（CFVR）。获得所有组的冠状动脉速度曲线。研究的冠状动脉血流参数在健康和高血压患者的每个阶段都具有可比性。

结果

平均舒张速度为 54.8 ± 12.9 vs. 51.8 ± 12.2 cm/s，50 W；69.2 ± 17.1 对比 64.4 ± 19.1 cm/s，75 W；70.7 ± 16.4 对比 76.1 ± 19.0 cm/s，100 W；80.0 ± 16.0 对比 72.9 ± 16.1 cm/s，125 W；在 150 W 时分别为 83.7 ± 12.2 和 81.4 ± 17.0，p 不显着。平均而言，健康组达到 CFVR > 2.0，心率为 110-120 次/分钟，75 W。在仰卧自行车运动期间，健康受试者和动脉高血压患者具有相似的冠状动脉血流速度曲线。

结论

常规运动超声心动图检查可以在常规仰卧运动负荷试验期间通过额外测量冠状动脉血流速度来补充，因为在次最大心率之前达到 CFVR 的正常范围。