Drug recalls have led to increased regulatory scrutiny into the formation and presence of nitrosamine (N-nitrosoamine) impurities in medicines. This review aims to assist the development of risk mitigation strategies by summarizing known reactions of nitrosamines, with a focus on reactions useful within the context of complex molecule synthesis. This review should serve as a useful reference and help lead to the development of chemical processes which effectively control nitrosamines.

中文翻译：

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亚硝胺反应性：反应和净化过程的调查

药品召回导致对药品中亚硝胺（N-亚硝基胺）杂质的形成和存在的监管审查增加。本综述旨在通过总结亚硝胺的已知反应来协助制定风险缓解策略，重点是在复杂分子合成的背景下有用的反应。该综述应作为有用的参考，并有助于开发有效控制亚硝胺的化学工艺。