当前位置: X-MOL 学术Radiat. Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Biological Effective Dose for Treatment of a Heterogeneous Population of Cells with a Spread-Out Bragg Peak of Particle Radiation
Radiation Research ( IF 3.4 ) Pub Date : 2021-07-14 , DOI: 10.1667/rade-20-00024.1
Roland B Hawkins 1
Affiliation  

Calculation of the biological effective dose (BED) of a fractionated course of hadron particle radiation (e.g., protons or carbon ions) administered via a spread-out Bragg peak (SOBP) to a population of cells with heterogeneous radiosensitivity is described. The calculated BED has the important property that, if equal to that of a course of photon radiation, the particle course will result in the same fraction of cells of the exposed population that survive and can be expected to have the same clinical effect. The calculated BED provides a way to relate the effect of a planned treatment course with particle radiation to clinical experience of the effects of treatment with low-LET photon radiation.



中文翻译:

用于治疗具有扩散的粒子辐射布拉格峰的异质细胞群的生物有效剂量

描述了通过展开的布拉格峰 (SOBP) 向具有异质放射敏感性的细胞群施用的强子粒子辐射(例如,质子或碳离子)的分次过程的生物有效剂量 ( BED ) 的计算。计算出的BED具有一个重要特性,即如果等于光子辐射过程的粒子过程,则粒子过程将导致暴露群体中相同比例的细胞存活并有望具有相同的临床效果。计算出的BED提供了一种将粒子辐射计划治疗过程的效果与低 LET 光子辐射治疗效果的临床经验联系起来的方法。

更新日期:2021-07-14
down
wechat
bug