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Allergy to Gibberellin-Regulated Proteins (Peamaclein) in Children
International Archives of Allergy and Immunology ( IF 2.8 ) Pub Date : 2021-07-19 , DOI: 10.1159/000517413
Benedetta Biagioni 1 , Leonardo Tomei 2 , Claudia Valleriani 3 , Giulia Liccioli 4 , Simona Barni 2 , Lucrezia Sarti 2 , Francesco Citera 3 , Mattia Giovannini 2 , Francesca Mori 2
Affiliation  

Background: Gibberellin-regulated proteins (GRPs, Peamaclein) are allergens recently identified in plant-derived food allergy (FA), and little is known about the clinical manifestations of this allergic condition in the European population, especially in children. Objective: Our study aimed to identify and characterize pediatric patients with pollen-FA due to GRP sensitization. Methods: We retrospectively analyzed the charts of patients referred to the Allergy Unit of the Meyer Children’s Hospital in Florence for suspected FA. Three main eligibility criteria based on the actual knowledge of GRP allergy were used to select patients deserving further investigations: (1) systemic reactions after consumption of fruit or an unknown culprit food, (2) positive skin prick tests to both cypress pollen and Pru p 3-enriched peach peel extracts, (3) negative in vitro test results for Pru p 3 serum-specific Immunoglobulin E (sIgE). We performed the in vitro test to determine the anti-rPru p 7 (Peamaclein) sIgE levels in the selected patients. Results: We identified 10 pediatric patients with Pru p 7 allergy and described their characteristics. The use of our eligibility criteria showed a high accuracy in identifying these patients: 100% of the selected patients had positive in vitro results for Pru p 7. We therefore proposed a diagnostic algorithm for Pru p 7 allergy. Conclusion: This is the first case series of European pediatric patients with a demonstrated Peamaclein allergy. These findings broaden our knowledge on GRP allergy in pediatric populations and could help clinicians to suspect, diagnose, and manage this recently discovered plant-derived FA.
Int Arch Allergy Immunol


中文翻译:

儿童对赤霉素调节蛋白(Peamaclein)过敏

背景:赤霉素调节蛋白(GRPs、Peamaclein)是最近在植物源性食物过敏 (FA) 中发现的过敏原,但对这种过敏性疾病在欧洲人群中的临床表现知之甚少,尤其是在儿童中。目的:我们的研究旨在识别和表征因 GRP 致敏而患有花粉-FA 的儿科患者。方法:我们回顾性分析了转诊至佛罗伦萨梅耶儿童医院过敏科的疑似 FA 患者的图表。根据对 GRP 过敏的实际知识,使用三个主要的合格标准来选择值得进一步研究的患者:(1)食用水果或未知罪魁祸首食物后的全身反应,(2)柏树花粉和 Pru p 的皮肤点刺试验阳性富含 3 的桃皮提取物,(3) Pru p 3 血清特异性免疫球蛋白 E (sIgE) 的体外测试结果为阴性。我们进行了体外测试,以确定所选患者的抗 rPru p 7 (Peamaclein) sIgE 水平。结果:我们确定了 10 名患有 Pru p 7 过敏症的儿科患者并描述了他们的特征。使用我们的资格标准显示出识别这些患者的准确性很高:100% 的选定患者的体外 Pru p 7 结果为阳性。因此,我们提出了 Pru p 7 过敏的诊断算法。结论:这是第一个对 Peamaclein 过敏的欧洲儿科患者的病例系列。这些发现拓宽了我们对儿科人群 GRP 过敏的认识,并可以帮助临床医生怀疑、诊断和管理这种最近发现的植物来源的 FA。
Int Arch 过敏免疫
更新日期:2021-07-19
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