Background. Despite evidence of ongoing epidemiological changes in deaths from venous thromboembolism in high-income countries, little recent information is available on the time trends in mortality related to PE as underlying or concomitant cause of death in Europe. Methods. We accessed the regional database of death certificates of Veneto Region (Northern Italy, population 4,900,000) from 2008 to 2019. We analysed the trends in crude and age-adjusted annual rates of mortality related to PE (reported either as underlying cause or in any position in the death certificate) using Joinpoint regression; in the contribution of PE to mortality (proportionate mortality); and, using logistic regression, in the association between PE and cancer at death. Results. Between 2008 and 2019, the age-standardized mortality rate related to PE in Veneto decreased from 20.7 to 12.6 annual deaths per 100,000 population for PE in any position of the death certificate, and from 4.6 to 2.2 annual deaths per 100,000 population for PE as underlying cause of death. PE-related proportionate mortality remained up to twice as high in women. The age- and sex-adjusted odds ratio for cancer in deaths with (vs. without) PE constantly increased from 1.01 (95% CI 0.88-1.16) in 2008 to 1.58 (95% CI 1.35-1.83) in 2019. Conclusions. The descending trend in PE-related mortality reported for Europe up to 2015 for both sexes continued thereafter in Northern Italy. However, sex differences in proportionate mortality persist, and the increasing association between PE and cancer at death may reflect changes in risk factor distribution or diagnostic practices.

中文翻译：

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2008-2019 年，威尼托地区（意大利）肺栓塞相关死亡率总体下降，癌症相关事件发生率上升

背景。尽管有证据表明高收入国家静脉血栓栓塞死亡的流行病学正在发生变化，但关于欧洲作为潜在或伴随死亡原因的 PE 相关死亡率的时间趋势的最新信息很少。方法。我们访问了 2008 年至 2019 年威尼托地区（意大利北部，人口 4,900,000）的死亡证明区域数据库。我们分析了与 PE 相关的粗略和年龄调整的年死亡率趋势（报告为根本原因或任何位置）在死亡证明中）使用 Joinpoint 回归；PE对死亡率的贡献（比例死亡率）；并且，使用逻辑回归，在 PE 与死亡癌症之间的关联中。结果。2008 年至 2019 年间，在威尼托，与 PE 相关的年龄标准化死亡率从每 100,000 人死亡证明中的任何位置的 PE 每年死亡 20.7 人下降到 12.6 人，而 PE 作为潜在死因的每年每 100,000 人死亡人数从 4.6 下降到 2.2 人。女性与 PE 相关的比例死亡率仍然高达两倍。经年龄和性别调整的癌症死亡风险比（与非）PE 不断增加，从 2008 年的 1.01（95% CI 0.88-1.16）增加到 2019 年的 1.58（95% CI 1.35-1.83）。结论。截至 2015 年，欧洲报告的 PE 相关死亡率呈下降趋势，此后意大利北部继续保持这种趋势。然而，成比例死亡率的性别差异仍然存在，PE与死亡时癌症之间的关联性增加可能反映了危险因素分布或诊断实践的变化。