Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique well known for its ability to elucidate structures and analyse mixtures and its quantitative nature. However, the cost and maintenance of high field NMR instruments prevent its widespread use by forensic chemists. The introduction of benchtop NMR spectrometers to the market operating at 40–80 MHz have a small footprint, are easy to use and cost much less than high field instruments, which makes them well suited to meet the needs of forensic chemists. These modern low field spectrometers are often capable of running multiple nuclei including ¹H, ¹³C, ¹⁹F and ³¹P; 2D NMR experiments and advanced experiments such as solvent suppression and diffusion-ordered spectroscopy (DOSY) are possible. This has resulted in a number of publications in the area of forensic chemistry using benchtop NMR spectroscopy in the last 5 years that was previously missing from the literature. This mini review summarises this research including examples of benchtop NMR being used to identify and quantify compounds relevant to forensics and some advanced methods that may be used to overcome some of the limitations of these instruments for forensic analysis. Further validation and automation are likely required for widespread uptake of benchtop NMR in industry; however, it has been demonstrated as a useful complement to other analytical techniques commonplace of forensic laboratories.

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法医化学中的台式核磁共振波谱

核磁共振 (NMR) 波谱是一项强大的技术，以其阐明结构和分析混合物的能力及其定量性质而闻名。然而，高场核磁共振仪器的成本和维护阻碍了法医化学家的广泛使用。在 40–80 MHz 频率下运行的台式核磁共振波谱仪在市场上的推出占地面积小，易于使用且成本远低于高场仪器，这使得它们非常适合满足法医化学家的需求。这些现代低场光谱仪通常能够运行多个原子核，包括¹ H、¹³ C、¹⁹ F 和³¹; 可以进行 2D NMR 实验和溶剂抑制和扩散有序光谱 (DOSY) 等高级实验。这导致在过去 5 年中使用台式 NMR 光谱法在法医化学领域发表了许多出版物，这在以前的文献中是缺失的。这篇简短的评论总结了这项研究，包括用于识别和量化与法医学相关的化合物的台式核磁共振示例，以及一些可用于克服这些法医学分析仪器的一些局限性的先进方法。在工业界广泛采用台式核磁共振可能需要进一步的验证和自动化；然而，它已被证明是对法医实验室其他常见分析技术的有益补充。