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The Microbiota–Gut–Brain Axis and Epilepsy
Cellular and Molecular Neurobiology ( IF 4 ) Pub Date : 2021-07-19 , DOI: 10.1007/s10571-021-01130-2
Qiang Yue 1 , Mingfei Cai 2 , Bo Xiao 1 , Qiong Zhan 2 , Chang Zeng 3
Affiliation  

Honoured as the second genome in humans, the gut microbiota is involved in a constellation of physiological and pathological processes, including those related to the central nervous system. The communication between the gut microbiota and the brain is realized by a complex bidirectional connection, known as the "microbiota-gut-brain axis", via neuroendocrine, immunological, and direct neural mechanisms. Recent studies indicate that gut dysfunction/dysbiosis is presumably involved in the pathogenesis of and susceptibility to epilepsy. In addition, the reconstruction of the intestinal microbiome through, for example, faecal microbiota transplantation, probiotic intervention, and a ketogenic diet, has exhibited beneficial effects on drug-resistant epilepsy. The purposes of this review are to provide a brief overview of the microbiota–gut–brain axis and to synthesize what is known about the involvement of the gut microbiota in the pathogenesis and treatment of epilepsy, to bring new insight into the pathophysiology of epilepsy and to present a preliminary discussion of novel therapeutic options for epilepsy based on the gut microbiota.



中文翻译:

微生物群-肠-脑轴与癫痫

肠道微生物群被誉为人类的第二个基因组,参与一系列生理和病理过程,包括与中枢神经系统相关的过程。肠道微生物群与大脑之间的交流是通过神经内分泌、免疫和直接神经机制通过复杂的双向连接实现的,称为“微生物群-肠道-脑轴”。最近的研究表明,肠道功能障碍/生态失调可能与癫痫的发病机制和易感性有关。此外,通过粪便微生物群移植、益生菌干预和生酮饮食等方式重建肠道微生物群,对耐药性癫痫表现出有益效果。

更新日期:2021-07-19
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