Abstract

New Mannich bases were synthesized from chiral norbornenylmethanol, secondary amines, and formaldehyde. Their structure was confirmed by elemental analyses and IR, ¹H and ¹³C NMR, and mass spectra. The products were optically active (dextrorotatory), and they showed high antimicrobial activity against Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, and yeast-like fungi of the family Candida, which exceeded the activity of some drugs currently used in medical paractice. Minimum inhibitory and minimum bactericidal concentrations of the synthesized compounds were determined.

中文翻译：

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含有降冰片烯片段的手性曼尼希碱的合成及抗菌性能

摘要

新的曼尼希碱是由手性降冰片烯甲醇、仲胺和甲醛合成的。它们的结构通过元素分析和 IR、¹ H 和¹³ C NMR 以及质谱得到证实。该产品具有旋光性（右旋），对金黄色葡萄球菌、肺炎克雷伯菌、大肠杆菌和念珠菌属酵母样真菌表现出很高的抗菌活性，其活性超过了目前医疗中使用的一些药物。测定合成化合物的最低抑菌浓度和最低杀菌浓度。