Abstract

Antimicrobial resistance not only increases the contagiousness of infectious diseases but also a threat for the future as it is one of the health care concern around the globe. Conventional antibiotics are unsuccessful in combating chronic infections caused by multidrug-resistant (MDR) bacteria, therefore it is important to design and develop novel strategies to tackle this problems. Among various novel strategies, Structurally Nanoengineered Antimicrobial Peptide Polymers (SNAPPs) have been introduced in recent years to overcome this global health care issue and they are found to be more efficient in their performance. Many facile methods are adapted to synthesize complex SNAPPs with required dimensions and unique functionalities. Their unique characteristics and remarkable properties have been exploited for their immense applications in various fields including biomedicine, targeting therapies, gene delivery, bioimaging, and many more. This review article deals with its background, design, synthesis, mechanism of action, and wider applications in various fields of SNAPPs.

Graphic abstract

中文翻译：

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结构纳米工程抗菌肽聚合物：设计、合成和生物医学应用

摘要

抗微生物药物耐药性不仅增加了传染病的传染性，而且对未来构成威胁，因为它是全球卫生保健问题之一。传统抗生素无法成功对抗由多重耐药 (MDR) 细菌引起的慢性感染，因此设计和开发解决这一问题的新策略非常重要。在各种新颖的策略中，近年来引入了结构纳米工程抗菌肽聚合物 (SNAPP) 以克服这一全球医疗保健问题，并且发现它们的性能更有效。许多简便的方法适用于合成具有所需尺寸和独特功能的复杂 SNAPP。它们独特的特性和卓越的特性已被开发用于各种领域的广泛应用，包括生物医学、靶向治疗、基因递送、生物成像等。这篇综述文章涉及其背景、设计、合成、作用机制以及在 SNAPP 各个领域中的更广泛应用。

图形摘要