B cell activating factor (BAFF or BLyS), an important cytokine for B cell survival and humoral immune responses, is targeted in the clinic for the treatment of systemic lupus erythematosus. This review focuses on the structure, function and inhibition profiles of membrane-bound BAFF, soluble BAFF 3-mer and soluble BAFF 60-mer, all of which have distinct properties. BAFF contains a loop region not required for receptor binding but essential for receptor activation via promotion of BAFF-to-BAFF contacts. This loop region additionally allows formation of BAFF 60-mer, in which epitopes of the BAFF inhibitor belimumab are inaccessible. If 60-mer forms in humans, it is predicted to be short-lived and to act locally because adult serum contains a BAFF 60-mer dissociating activity. Cord blood contains elevated levels of BAFF, part of which displays attributes of 60-mer, suggesting a role for this form of BAFF in the development of foetal or neonate B cells.

中文翻译：

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不同形式BAFF的功能、发生和抑制。

B 细胞激活因子（BAFF 或 BLyS）是 B 细胞存活和体液免疫反应的重要细胞因子，是临床治疗系统性红斑狼疮的靶点。本综述重点介绍了膜结合 BAFF、可溶性 BAFF 3-mer 和可溶性 BAFF 60-mer 的结构、功能和抑制谱，它们都具有不同的特性。BAFF 包含一个环区，该环区不是受体结合所必需的，但对于通过促进 BAFF 与 BAFF 接触来激活受体至关重要。该环区还允许形成 BAFF 60-mer，其中 BAFF 抑制剂 belimumab 的表位是不可接近的。如果 60-mer 在人类中形成，预计它是短暂的并且会在局部起作用，因为成人血清含有 BAFF 60-mer 解离活性。脐带血中的 BAFF 水平升高，