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Adult Vaccination, Getting to Know Their Nonspecific Effects
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ( IF 5.1 ) Pub Date : 2021-07-31 , DOI: 10.1093/gerona/glab202
Charles L Greenblatt 1 , Hervé Bercovier 1 , Benjamin Y Klein 1 , Ofer N Gofrit 2
Affiliation  

We are writing to the Journal of Gerontology to thank them for the publication of “Lower risk for dementia following adult tetanus, diphtheria and pertussis (Tdap) vaccination” by Scherrer et al. (1). The authors found in 2 different cohorts, an overall reduction of dementia of 42%. This was in spite of differences in gender, socioeconomic status, and medical histories. The authors accounted for confounding factors by a reweighting of the data and noted the limitations of this type of study. We can now add a number of immunizations that have been reported to reduce dementia, which is mostly accounted for by Alzheimer’s disease (AD). These include in addition to DPT, tetanus or diphtheria alone, anti-influenza, anti-pneumonia, and Bacille Calmette–Guérin (BCG), the 100-year-old antituberculosis vaccine (2–5). Shingles is also reported as “under review” (1). One thinks of a specific vaccine for a specific disease, but these reports aim at the “nonspecific effects” (NSE) of these vaccines.

中文翻译:

成人疫苗接种,了解它们的非特异性影响

我们正在写信给老年学杂志感谢他们发表了 Scherrer 等人的“成人破伤风、白喉和百日咳 (Tdap) 疫苗接种后患痴呆症的风险降低”。(1). 作者在 2 个不同的队列中发现,痴呆症总体减少了 42%。尽管在性别、社会经济地位和病史方面存在差异。作者通过重新加权数据来解释混杂因素,并指出了此类研究的局限性。我们现在可以添加一些据报道可以减少痴呆症的免疫接种,这主要是由阿尔茨海默病 (AD) 引起的。除了百白破之外,这些还包括单独的破伤风或白喉、抗流感、抗肺炎和卡介苗 (BCG),一种已有 100 年历史的抗结核疫苗 (2-5)。带状疱疹也被报告为“正在审查”(1)。
更新日期:2021-09-29
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