Transcutaneous monitoring is a noninvasive method to continuously measure the partial pressures of oxygen and carbon dioxide that diffuse through the skin and correlate closely with changes in blood gases. However, the contemporary commercially available electrochemical-based technology requires a heating mechanism and a bulky, corded, and expensive sensing unit. This study aims to demonstrate a prototype noninvasive, miniaturized monitor that uses luminescence-based technology to measure the partial pressure of transcutaneous oxygen, a surrogate of the partial pressure of arterial oxygen. To be able to build a robust measurement system, we conducted experiments to understand the temperature and humidity dependence of oxygen-sensitive platinum-porphyrin films. We performed a detailed analysis of both intensity and lifetime measurement techniques. To verify the performance, we tested the prototype in a small ex-vivo experiment involving three healthy human volunteers. We measured variations in the partial pressure of transcutaneous oxygen values due to pressure-induced arterial and venous occlusions on the volunteers’ fingertips. The system resolves changes in the partial pressure of oxygen from 0 to 418 mmHg in the lab bench-top testing, covering the medically relevant range of 50-150 mmHg. Under fixed humidity, temperature, and the partial pressure of oxygen conditions, the sensor shows a 2% drift over 60 hours. The prototype consumes 9 mW of power from a 2.2 V external DC power supply.

中文翻译：

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一种无创微型经皮氧监测仪

经皮监测是一种无创方法，可连续测量通过皮肤扩散并与血气变化密切相关的氧气和二氧化碳分压。然而，当代市售的基于电化学的技术需要加热机制和笨重、有绳且昂贵的传感单元。本研究旨在展示一种原型无创微型监测器，该监测器使用基于发光的技术来测量经皮氧分压，这是动脉氧分压的替代品。为了能够建立一个强大的测量系统，我们进行了实验来了解氧敏感铂卟啉薄膜的温度和湿度依赖性。我们对强度和寿命测量技术进行了详细分析。为了验证性能，我们在一个涉及三名健康人类志愿者的小型体外实验中测试了原型。我们测量了由于志愿者指尖上的压力引起的动脉和静脉闭塞引起的经皮氧分压值的变化。该系统解决了实验室台式测试中氧气分压从 0 到 418 mmHg 的变化，涵盖了 50-150 mmHg 的医学相关范围。在固定的湿度、温度和氧气分压条件下，传感器在 60 小时内显示出 2% 的漂移。该原型从 2.2 V 外部直流电源消耗 9 mW 的功率。我们测量了由于志愿者指尖上的压力引起的动脉和静脉闭塞引起的经皮氧分压值的变化。该系统解决了实验室台式测试中氧气分压从 0 到 418 mmHg 的变化，涵盖了 50-150 mmHg 的医学相关范围。在固定的湿度、温度和氧气分压条件下，传感器在 60 小时内显示出 2% 的漂移。该原型从 2.2 V 外部直流电源消耗 9 mW 的功率。我们测量了由于志愿者指尖上的压力引起的动脉和静脉闭塞引起的经皮氧分压值的变化。该系统解决了实验室台式测试中氧气分压从 0 到 418 mmHg 的变化，涵盖了 50-150 mmHg 的医学相关范围。在固定的湿度、温度和氧气分压条件下，传感器在 60 小时内显示出 2% 的漂移。该原型从 2.2 V 外部直流电源消耗 9 mW 的功率。传感器在 60 小时内显示出 2% 的漂移。该原型从 2.2 V 外部直流电源消耗 9 mW 的功率。传感器在 60 小时内显示出 2% 的漂移。该原型从 2.2 V 外部直流电源消耗 9 mW 的功率。