The present study was conducted to evaluate the effect of Forsythiae Fructus aqueous extract (FAE) against cisplatin-induced emesis and to explore the antiemetic mechanism of FAE by focusing on NLRP3 inflammasome activation in a rat pica model. Our results showed that FAE significantly ameliorated cisplatin-induced acute and delayed pica in rats. Moreover, FAE improved the gastrointestinal histopathological injury and reduced the levels of serum ROS, IL-1β, and IL-18 in cisplatin-treated rats. In addition, the expressions of NLRP3, ASC, caspase-1, and IL-1β and the colocalization of the NLRP3 with ASC or caspase-1 in rat gastric antrum and ileum were also suppressed by FAE. Taken together, our findings indicate that FAE has a therapeutic effect against CINV, which may be related to its inhibition of the activation of NLRP3 inflammasome.

中文翻译：

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Forsythiae Fructus 水提取物通过抑制大鼠 NLRP3 炎性体活化来减弱顺铂诱导的高岭土消耗（异食癖）。

本研究旨在评估连翘水提物 (FAE) 对顺铂诱导的呕吐的作用，并通过关注大鼠异食癖模型中 NLRP3 炎性体的激活来探索 FAE 的止吐机制。我们的研究结果表明，FAE 显着改善了顺铂诱导的大鼠急性和延迟异食癖。此外，FAE 改善了胃肠道组织病理学损伤，降低了顺铂治疗大鼠的血清 ROS、IL-1β 和 IL-18 水平。此外，大鼠胃窦和回肠中 NLRP3、ASC、caspase-1 和 IL-1β 的表达以及 NLRP3 与 ASC 或 caspase-1 的共定位也被 FAE 抑制。总之，我们的研究结果表明 FAE 对 CINV 具有治疗作用，这可能与其抑制 NLRP3 炎性体的激活有关。