Atmospheric pressure drift tube ion mobility was coupled with two-dimensional tandem mass spectrometry (2D MS/MS) in a linear ion trap to simultaneously collect ion mobility and the entire MS/MS data domain. Utilizing ion intensities from precursor ion and neutral loss scan lines, ion mobility spectra of multiple compounds with particular functional groups were acquired in a single experiment. Functional group-specific ion mobility spectra were demonstrated for a standard mixture of lipids. Additionally, ion mobility was used to separate isobaric ions prior to 2D MS/MS. The combination of these two methods offers improvements for the analysis of complex mixtures.

中文翻译：

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大气压力漂移管离子迁移谱与二维串联质谱联用。

大气压漂移管离子迁移率与线性离子阱中的二维串联质谱 (2D MS/MS) 相结合，以同时收集离子迁移率和整个 MS/MS 数据域。利用来自母离子和中性丢失扫描线的离子强度，在一次实验中获得了具有特定官能团的多种化合物的离子迁移谱。对标准脂类混合物展示了官能团特定的离子迁移谱。此外，离子淌度用于在 2D MS/MS 之前分离同量异位离子。这两种方法的结合为复杂混合物的分析提供了改进。