Composite poly-L-lactide acid-based scaffolds with hydroxyapatite (HAp) content up to 75 wt.% were fabricated via solution blow spinning. The influence of HAp concentration on structure, wettability, mechanical properties and chemical and phase composition of the produced materials was examined. It was found that with an increase of HAp content the average fiber diameter was increased, the uniaxial strength and relative elongation were reduced, while the phase composition and surface wettability did not change. The performance of the scaffolds during implantation in the parietal bone of a rat skull for a period from 15 to 90 days was studied. The materials have shown high ability to integrate with both soft and hard tissues. It was found that scaffolds with 25 wt.% HAp content significantly enhance osteogenesis during scarification (damage) of the periosteum. Overall, the fabricated scaffolds proved to be highly efficient for replacing bone defects in long tubular bones.

通过溶液吹纺法制造了羟基磷灰石 (HAp) 含量高达 75 wt.% 的复合聚 L-丙交酯酸基支架。检查了HAp浓度对所生产材料的结构、润湿性、机械性能以及化学和相组成的影响。研究发现，随着HAp含量的增加，平均纤维直径增加，单轴强度和相对伸长率降低，而相组成和表面润湿性没有变化。研究了支架在植入大鼠颅骨顶骨 15 至 90 天期间的性能。这些材料已显示出与软组织和硬组织结合的高能力。发现支架具有 25 wt. ％HAp含量显着增强骨膜划痕（损伤）期间的成骨。总体而言，事实证明，制造的支架对于替换长管状骨中的骨缺损非常有效。