BACKGROUND Contrary to what happens in children and adults, the prevalence and the factors related to hospitalisation for asthma/wheezing in infants with recurrent asthma-like symptoms are poorly known. METHODS This study is part of the International Study of Wheezing in infants Phase 3; 2,079 infants (aged 12-18 months) with recurrent asthma-like symptoms, from 11 South American centres, were studied to determine the prevalence and the associated factors for wheezing exacerbation admission. Descriptive statistics and multivariate logistic regression were employed for analysis. RESULTS The prevalence of admission for wheezing was 29.7% (95% CI 27.7-31.6) and was significantly associated to severe wheezing episodes (OR: 3.89; 95% CI: 2.93-5.18, p < 0.001), physician-diagnosed asthma (OR: 1.79; 95% CI: 1.33-2.41, p < 0.0001), use of inhaled corticosteroids (OR: 1.78; 95%CI: 1.38-2.29, p < 0.0001), maternal tobacco smoking during pregnancy (OR: 1.69; 95% CI: 1.19-2.39, p = 0.003) and onset of wheezing in the first trimester of life (OR: 1.30; 95% CI: 1.02-1.66, p = 0.038). Breast feeding ≥4 months (OR: 0.72; 95% CI: 0.54-0.96, p = 0.004), maternal high educational level (>12 years) (OR: 0.66; 95% CI: 0.51-0.85, p = 0.001) and total monthly household income ≥US$ 3,000 (OR: 0.34; 95% CI: 0.18-0.67, p = 0.002), were protective factors. CONCLUSIONS Infants with recurrent asthma-like symptoms have a high rate of admissions. Tobacco smoking in pregnancy, viral respiratory illness in the first trimester of life and severe progression were risks for admissions. Improving medical management to prevent severe exacerbations, prolonging the postnatal period at home longer than 3 months, favouring breastfeeding and avoiding smoking during pregnancy may have a preventive role for admissions in infants with recurrent asthma-like symptoms.

中文翻译：

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2,075 名患有复发性哮喘样症状的婴儿因症状加重而入院：（EISL-3 南美洲）。

背景与儿童和成人中发生的情况相反，对具有复发性哮喘样症状的婴儿的哮喘/喘息住院的患病率和相关因素知之甚少。方法 本研究是国际婴儿喘息研究 3 期的一部分；研究了来自 11 个南美中心的 2,079 名反复出现哮喘样症状的婴儿（12-18 个月），以确定喘息加重入院的患病率和相关因素。采用描述性统计和多元逻辑回归进行分析。结果 因喘息入院的患病率为 29.7% (95% CI 27.7-31.6)，并且与严重喘息发作显着相关 (OR: 3.89; 95% CI: 2.93-5.18, p < 0.001)、医生诊断的哮喘 (OR : 1.79; 95% CI: 1.33-2.41, p < 0.0001), 使用吸入性皮质类固醇（OR：1.78；95%CI：1.38-2.29，p < 0.0001），孕期吸烟（OR：1.69；95% CI：1.19-2.39，p = 0.003）和喘息发作生命的头三个月（OR：1.30；95% CI：1.02-1.66，p = 0.038）。母乳喂养 ≥4 个月（OR：0.72；95% CI：0.54-0.96，p = 0.004），母亲受教育程度高（>12 岁）（OR：0.66；95% CI：0.51-0.85，p = 0.001）和家庭月总收入 ≥ 3,000 美元（OR：0.34；95% CI：0.18-0.67，p = 0.002）是保护因素。结论 反复出现哮喘样症状的婴儿的入院率很高。怀孕期间吸烟、生命头三个月的病毒性呼吸道疾病和严重进展是入院的风险。加强医疗管理，防止病情严重恶化，