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Evaluation of atherogenic lipoprotein-cholesterol to HDL cholesterol ratio as a prognostic test for ST-segment elevation myocardial infarction
International Journal of Medical Sciences ( IF 3.6 ) Pub Date : 2021-6-4 , DOI: 10.7150/ijms.44801
Jia-Yong Li 1 , Wen-Jun Xu 1 , Zhe Zhou 1, 2 , Ru-Lin Zhang 1 , Ting Sun 3 , Hao Xu 4 , Jun Wu 5
Affiliation  

Background: The detectable component of triglyceride-rich lipoproteins (TGRLs), remnant lipoprotein cholesterol (RLP-c), has been proven being correlated with the progression of atherosclerosis and myocardial infarction. However, when taken as a risk predictor, the prognostic and diagnostic potential of RLP-c remains controversial in studies. In this study, we evaluated the hypothesis that atherogenic lipoprotein-cholesterol (AL-c), representing the sum of RLP-c and the sd-LDL-c, to the HDL-c ratio, could represent a better predictive indicator than RLP-c alone in ST-segment elevation myocardial infarction (STEMI)./nMethods: The 316 consecutive patients suffering from persistent chest discomfort admitted to the Shanghai General Hospital between January 2018 and June 2018 were enrolled. 149 STEMI patients (62% men, mean age 69.6 ± 13.3 years) were included as the study cohort. The AL-c/HDL-c ratio was calculated on admission in a cohort of electrocardiogram-confirmed STEMI patients and compared to other lipid profiles as a predictive indicator./nResults: The AL-c/HDL-c ratio was significantly increased in STEMI patients compared with apparently healthy adults (0.93; IQR [0.71-1.18] vs 0.70; IQR [0.45-1.04]; p < 0.001). Gender dependency existed, and the male and female patients had median AL-c/HDL-c ratios of 1.01 and 0.79, respectively (p < 0.001). Compared to RLP-c, the AL-c/HDL-c ratio had a better prognostic value to predict STEMI risk in both sexes (AUC of 0.672 with a sensitivity of 0.794 in males and 0.613 with a sensitivity of 0.684 in females)./nConclusions: The AL-c/HDL-c ratio could represent a convenient and sensitive biomarker for screening and predicting STEMI risk.

中文翻译:

评估致动脉粥样硬化的脂蛋白胆固醇与高密度脂蛋白胆固醇的比率作为 ST 段抬高心肌梗死的预后测试

背景:富含甘油三酯的脂蛋白 (TGRL) 的可检测成分残留脂蛋白胆固醇 (RLP-c) 已被证明与动脉粥样硬化和心肌梗塞的进展相关。然而,当作为风险预测因子时,RLP-c 的预后和诊断潜力在研究中仍然存在争议。在这项研究中,我们评估了以下假设,即致动脉粥样硬化脂蛋白胆固醇 (AL-c),代表 RLP-c 和 sd-LDL-c 的总和,与 HDL-c 的比率,可以代表比 RLP-c 更好的预测指标c 单独用于 ST 段抬高型心肌梗死 (STEMI)。/n方法:纳入上海总医院2018年1月至2018年6月连续收治的316例持续性胸部不适患者。149 名 STEMI 患者(62% 男性,平均年龄 69.6 ± 13.3 岁)被纳入研究队列。AL-c/HDL-c 比值是在一组心电图确诊的 STEMI 患者入院时计算的,并与其他血脂谱进行比较作为预测指标。/n 结果: AL-c/HDL-c 比值在STEMI 患者与表面健康的成年人相比(0.93;IQR [0.71-1.18] vs 0.70;IQR [0.45-1.04];p < 0.001)。存在性别依赖性,男性和女性患者的 AL-c/HDL-c 比率中位数分别为 1.01 和 0.79(p< 0.001)。与 RLP-c 相比,AL-c/HDL-c 比率在预测男女 STEMI 风险方面具有更好的预后价值(男性的 AUC 为 0.672,敏感性为 0.794,女性的敏感性为 0.613,敏感性为 0.684)。/ n结论: AL-c/HDL-c 比值可以代表一种方便且灵敏的生物标志物,用于筛查和预测 STEMI 风险。
更新日期:2021-07-28
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