OBJECTIVE Depression is typically seen as composed of several factors (i.e., cognitive, affective, somatic) which may be targeted by different interventions (i.e., pharmacotherapy, psychotherapy, or combination treatment). Successfully targeting these factors may contribute to improved treatment response in depression. A previous study identified two subfactors on Beck Depression Inventory-II (BDI-II) in a sample of chronically depressed patients: (a) self-criticism and (b) somatic symptoms (sleep disturbance, fatigue, changes in appetite). Prior research indicates that these symptoms may respond differently to psychotherapy and pharmacotherapy. In this study, we examined whether patients who were on antidepressant medication (ADM) had different outcomes on these factors than patients not using medication while undergoing intensive inpatient psychotherapeutic treatment. METHOD After adjusting for baseline difference with propensity score matching, a total of 238 patients with chronic depression were included in the analysis of which 119 patients were using ADM during treatment while 119 were not. We analyzed whether the two groups had different trajectories of change on the factors "self-criticism" and "somatic symptoms" using multilevel growth curve modeling. RESULTS Patients not using medication during treatment had significantly larger symptom reduction than ADM users on the self-criticism factor, while there was no difference between groups on the somatic factor. CONCLUSION There seems to be a difference in outcomes on self-criticism depending on the use of ADM for this patient group. This may suggest that the simultaneous use of ADM while in psychotherapy could make patients less accessible to the effects of psychotherapeutic interventions on this factor. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

中文翻译：

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慢性抑郁症的变化轨迹：抗抑郁药使用者和非药物患者之间自我批评和躯体症状的差异。

目标抑郁症通常被视为由多种因素（即认知、情感、躯体）组成，这些因素可能是不同干预措施（即药物治疗、心理治疗或联合治疗）的目标。成功针对这些因素可能有助于改善抑郁症的治疗反应。先前的一项研究在慢性抑郁症患者样本中确定了贝克抑郁量表-II (BDI-II) 的两个子因素：(a) 自我批评和 (b) 躯体症状（睡眠障碍、疲劳、食欲变化）。先前的研究表明，这些症状对心理治疗和药物治疗的反应可能不同。在这项研究中，我们检查了服用抗抑郁药物 (ADM) 的患者在这些因素上的结果是否与在接受强化住院心理治疗期间不使用药物的患者有不同的结果。方法 通过倾向评分匹配调整基线差异后，共有 238 名慢性抑郁症患者被纳入分析，其中 119 名患者在治疗期间使用 ADM，119 名未使用。我们使用多级增长曲线模型分析了两组在“自我批评”和“躯体症状”因素上是否存在不同的变化轨迹。结果 治疗期间不服药的患者在自我批评因素上的症状减轻明显大于ADM使用者，而在躯体因素方面无组间差异。结论 根据该患者组使用 ADM 的情况，自我批评的结果似乎有所不同。这可能表明，在心理治疗中同时使用 ADM 可能会使患者难以接受心理治疗干预对该因素的影响。（PsycInfo 数据库记录 (c) 2022 APA，保留所有权利）。