Traditional metal materials, such as stainless steel and titanium (Ti) alloys, are still the gold standards for fracture fixation. However, the elastic moduli of these materials differ from that of human cortical bone, and the stress shielding effect affects fracture healing, leading to secondary fractures. Herein, a new porous Ta coated SiC (pTa-SiC) scaffold using in internal fixation devices with good mechanical and biological properties was prepared based on porous silicon carbide (SiC) scaffold and tantalum (Ta) metal. The osteogenic and osseointegration properties of the pTa-SiC scaffold were investigated by both in vitro and in vivo tests. The results showed that compared with porous titanium (pTi), the pTa-SiC promoted the proliferation, migration, and osteogenic differentiation of human bone marrow–derived mesenchymal stem cells. Moreover, the internal fixation tests were carried out in a goat load-bearing femoral neck fracture model. Histological results showed good osseointegration around the pTa-SiC screws. And the acid etching results showed that bone cells grew tightly on the pTa-SiC throughout bone canaliculi, and the growth mode was contact osteogenesis, which indicated good biological fixation effects. Therefore, it is reasonable to be expected that the new pTa-SiC scaffold with excellent mechanical and biological properties could be a promising candidate for bone implant field.

传统的金属材料，如不锈钢和钛 (Ti) 合金，仍然是骨折固定的金标准。但这些材料的弹性模量与人体皮质骨不同，应力屏蔽作用影响骨折愈合，导致继发性骨折。在此，基于多孔碳化硅（SiC）支架和钽（Ta）金属制备了一种用于内固定装置的具有良好机械和生物学性能的新型多孔钽涂层碳化硅（pTa-SiC）支架。通过体外和体内研究了 pTa-SiC 支架的成骨和骨整合特性测试。结果表明，与多孔钛（pTi）相比，pTa-SiC促进了人骨髓间充质干细胞的增殖、迁移和成骨分化。此外，在山羊承重股骨颈骨折模型中进行了内固定试验。组织学结果显示 pTa-SiC 螺钉周围有良好的骨整合。酸蚀结果表明，骨细胞在整个骨小管的pTa-SiC上紧密生长，生长方式为接触成骨，具有良好的生物固定效果。因此，可以合理预期具有优异机械和生物学性能的新型 pTa-SiC 支架可能成为骨植入领域的有希望的候选者。