Morphofunctional changes of the brain tissues of Wistar rats were studied based on the development of a multifactor cardiovasorenal model of arterial hypertension using MRI. An increase of the signal on the diffusion brain maps was recorded in 3 months, which indicated fluid accumulation in the intra- and extracellular space of the brain tissue. The data characterize the development of the pathogenetic mechanism of the hypervolemic variant of experimental arterial hypertension. The development of endothelial dysfunction in the brain vessels was manifested by predominance of abnormal constrictor reactions. In 6 months after arterial hypertension simulation, structural changes in the brain developed, such as leukoareosis, cystic encephalomalacia with dilated cerebrospinal fluid spaces and limited blood supply to brain tissue in the basins of the large cerebral arteries.

中文翻译：

---

使用扩散加权 MRI 估计高血压 Wistar 大鼠大脑的形态功能状态。

基于使用 MRI 建立的动脉高血压多因素心血管模型，研究了 Wistar 大鼠脑组织的形态功能变化。在 3 个月内记录到弥散脑图上的信号增加，这表明脑组织的细胞内和细胞外空间中存在液体积聚。这些数据表征了实验性动脉高血压的高血容量变异的发病机制的发展。脑血管内皮功能障碍的发展主要表现为异常缩窄反应。在动脉高血压模拟后的 6 个月内，大脑的结构发生了变化，例如白质疏松、