A confined direct analysis in a real time mass spectrometry (DART-MS) system and method were developed for coupling directly with commercial electronic cigarettes for rapid analysis without sample preparation. The system consisted of a confining heated glass T-junction, DART ionization source, and Vapur interface to assist aerodynamic transport. Suction generated by positioning the electronic cigarette at the junction inlet allowed for direct chemical analysis of aerosolized electronic liquids from both automatic devices powered by drag and manual button-operated devices, which is unachievable with traditional DART-MS. Parametric analyses for the system investigated Vapur suction flow rate, junction heating, puff duration, and coil power levels. Using this method, rapid chemical analyses of electronic cigarette aerosols from electronic liquids, spiked illicit drugs, and polymeric or plasticizer contaminants were performed in <30 s. The confined DART-MS method provides a streamlined tool for rapid screening of illicit and hazardous chemical profiles emitting from electronic cigarettes.

中文翻译：

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用于电子香烟气溶胶和加标药物快速化学分析的密闭 DART-MS。

开发了实时质谱 (DART-MS) 系统和方法中的限制性直接分析，用于直接与商用电子香烟耦合，无需样品制备即可进行快速分析。该系统由一个封闭的加热玻璃 T 型接头、DART 电离源和 Vapur 接口组成，以协助空气动力学传输。通过将电子香烟定位在连接入口处产生的吸力允许对来自拖动驱动的自动设备和手动按钮操作设备的雾化电子液体进行直接化学分析，这是传统 DART-MS 无法实现的。该系统的参数分析研究了 Vapur 吸入流量、结温、抽吸持续时间和线圈功率水平。使用这种方法，从电子液体中快速化学分析电子香烟气溶胶，加标非法药物和聚合物或增塑剂污染物的检测时间不到 30 秒。密闭 DART-MS 方法提供了一种简化的工具，用于快速筛查电子香烟释放的非法和危险化学成分。