An extract of date (fruit of a palm tree) residue plus food-grade glutamate, acetic acid, and yeast extract (date residue extract mix, DREM) has been successfully fermented with using Lactobacillus brevis JCM 1059T to produce gamma-aminobutyric acid (GABA). Here, mouse splenocytes were found to be viable when supplemented with DREM and fermented DREM containing GABA (fDREM). The addition of DREM and fDREM resulted in the secretion of tumor necrosis factor (TNF)-α from the splenocytes, fDREM being more effective than DREM. The TNF-α secretion with DREM was elevated by exogenous addition of GABA and that with fDREM was in part mediated via A-type GABA receptors. Contrary to general understanding of the suppressive effects of GABA on various biological functions, our findings suggest that GABA-containing fDREM arguments the immune function as a food and pharmaceutical material.

中文翻译：

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含有γ-氨基丁酸的发酵枣渣提取物混合物可增强小鼠脾细胞的免疫功能。

一种椰枣（棕榈树果实）提取物加上食品级谷氨酸盐、醋酸和酵母提取物（枣渣提取物混合物，DREM）已成功使用短乳杆菌 JCM 1059T 发酵生产γ-氨基丁酸（GABA） ）。在这里，发现小鼠脾细胞在补充 DREM 和含有 GABA 的发酵 DREM (fDREM) 时是有活力的。DREM 和 fDREM 的加入导致脾细胞分泌肿瘤坏死因子 (TNF)-α，fDREM 比 DREM 更有效。DREM 的 TNF-α 分泌通过外源性添加 GABA 升高，而 fDREM 的 TNF-α 分泌部分通过 A 型 GABA 受体介导。与 GABA 对各种生物功能的抑制作用的一般理解相反，