Following recent Newcastle disease virus (NDV) outbreaks in Iranian poultry farms which were mostly associated with lesions of the avian gastrointestinal tract, it was speculated that the scale of the outbreaks could be attributed in part to co-circulating infectious agents or a new NDV genotype/subgenotype. This speculation was due to the isolation of a few 5^th panzootic subgenotype VII.2 viruses from Iranian poultry farms in 2017. Samples from different species of commercial and domestic birds were collected from different provinces of Iran, 19 of which were selected for the current study. Phylogenetic analyses showed that the recent outbreaks have been caused by only one agent, i.e. the distinctive NDV subgenotype VII.1.1 (previously known VIIl) viruses that seem to be circulating predominantly in Iran, but have also been sporadically reported from Iraq among neighbouring countries. At most, 96.3–96.7% BLAST identity to non-Iranian VII.1.1 isolates was observed. Genetic distance values of <1% were indicative of high similarity between the isolates, but the values were approaximately 2% when the current isolates were compared to the earliest recorded Iranian VII.1.1 viruses isolated in 2010. Using Bayesian analysis, annual mutation rates of 1.7156E-3 (strict) and 1.9902E-3 (relaxed) over 11 years were obtained. In addition, we report that our laboratories have not detected any genotype XIII strains since 2011. Following up on previous reports, we concluded that currently, and except in Columbiforms, subgenotype VII.1.1 may likely be the predominant subgenotype in many bird species in Iran despite the subgenotype VII.2 being predominant in neighbouring countries.

在伊朗家禽养殖场最近爆发新城疫病毒 (NDV) 之后，该病毒主要与禽胃肠道病变有关，据推测，爆发的规模可能部分归因于共同传播的传染性病原体或新的 NDV 基因型/亚基因型。这个推测是由于几个5的隔离^次2017 年来自伊朗家禽养殖场的泛动物亚基因型 VII.2 病毒。从伊朗不同省份收集了不同种类的商业和家禽的样本，其中 19 种被选择用于当前研究。系统发育分析表明，最近的暴发仅由一种病原体引起，即独特的 NDV 亚基因型 VII.1.1（以前已知的 VIIl）病毒似乎主要在伊朗流行，但在邻国伊拉克也有零星报道。最多观察到 96.3-96.7% BLAST 与非伊朗 VII.1.1 分离株的同一性。<1% 的遗传距离值表明分离株之间的高度相似，但当将当前分离株与 2010 年分离的最早记录的伊朗 VII.1.1 病毒进行比较时，该值约为 2%。使用贝叶斯分析，获得了 11 年间 1.7156E-3（严格）和 1.9902E-3（宽松）的年突变率。此外，我们报告说，自 2011 年以来，我们的实验室没有检测到任何基因型 XIII 菌株。根据之前的报告，我们得出结论，目前，除了哥伦比目，亚基因型 VII.1.1 可能是伊朗许多鸟类的主要亚基因型尽管亚基因型 VII.2 在邻国占主导地位。