An experiment was conducted to evaluate the effects of including canola meal (CM) in diets for weaning pigs challenged with a F18 strain of Escherichia coli on growth performance and gut health. A total of 36 individually housed weaned pigs (initial body weight [BW] = 6.22 kg) were randomly allotted to one of the three diets (12 pigs/diet). The three diets were corn–soybean meal (SBM)-based basal diet (control diet) and the basal diet with 0.3% zinc oxide, 0.2% chlortetracycline, and 0.2% tiamulin (antibiotic diet) or with 20% CM diet. The diets were fed in two phases: Phase 1: days 0 to 7 and Phase 2: days 7 to 20. All pigs were given an oral dose of 2 × 109 CFU of F18 strain of E. coli on day 7. Fecal score was assessed daily throughout the trial. Dietary antibiotics increased (P < 0.05) overall average daily gain (ADG) and average daily feed intake (ADFI) compared by 48% and 47%, respectively. Dietary CM increased (P < 0.05) overall ADG and ADFI by 22% and 23%, respectively; but the ADG and ADFI values for CM-containing diet did not reach those for the antibiotics-containing diet. Dietary antibiotics reduced (P < 0.05) fecal score; however, dietary CM unaffected fecal score. Dietary antibiotics decreased (P < 0.05) liver weight per unit live BW by 16% at day 20, whereas dietary CM did not affect liver weight per unit live BW (29.2 vs. 28.6). Also, dietary antibiotics increased (P < 0.05) serum triiodothyronine and tetraiodothyronine levels for day 14, whereas dietary CM did not affect the serum level of these hormones. Dietary antibiotics reduced (P < 0.05) the number white blood cells and neutrophils by 38% and 43% at day 20, respectively, whereas dietary CM tended to reduce (P = 0.09) the number white blood cells by 19% at day 20. The number white blood cells for CM diet tended to be greater (P < 0.10) than that for antibiotics diet. The dietary antibiotics decreased (P < 0.05) the concentration of individual volatile fatty acids and hence of total volatile fatty acid in cecum by 61% at day 20, whereas dietary CM decreased (P < 0.05) cecal butyric acid concentration by 61% and tended to reduce (P < 0.10) total volatile fatty acid concentration by 30% at day 20. In conclusion, the dietary inclusion of 20% CM improved ADG and tended to reduce white blood cell counts. Thus, inclusion of CM in antibiotics-free corn-SBM-based diets for weaned pigs that are challenged with F18 strain of E. coli can result in their improved performance partly through a reduction of the inflammatory response.

中文翻译：

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饲喂含双低菜粕日粮的大肠杆菌攻击断奶仔猪的生长性能和肠道健康

进行了一项实验，以评估在日粮中添加双低菜粕 (CM) 对受到大肠杆菌 F18 菌株攻击的断奶猪的生长性能和肠道健康的影响。总共 36 头单独饲养的断奶猪（初始体重 [BW] = 6.22 kg）被随机分配到三种饮食中的一种（12 头猪/饮食）。三种日粮分别是基于玉米-豆粕 (SBM) 的基础日粮（对照日粮）和含 0.3% 氧化锌、0.2% 金霉素和 0.2% 泰妙菌素（抗生素日粮）或 20% CM 日粮的基础日粮。日粮分两个阶段饲喂：第 1 阶段：第 0 至 7 天和第 2 阶段：第 7 至 20 天。所有猪在第 7 天口服剂量为 2 × 109 CFU 的 F18 大肠杆菌菌株。粪便评分为在整个试验过程中每天评估。膳食抗生素增加（P < 0。05) 总体平均日增重 (ADG) 和平均日采食量 (ADFI) 相比分别提高了 48% 和 47%。膳食 CM 使总 ADG 和 ADFI 分别增加（P < 0.05）22% 和 23%；但含 CM 日粮的 ADG 和 ADFI 值未达到含抗生素日粮的 ADG 和 ADFI 值。膳食抗生素降低（P < 0.05）粪便评分；然而，饮食 CM 不影响粪便评分。在第 20 天，膳食抗生素使每单位活 BW 的肝重减少了 16%（P < 0.05），而膳食 CM 不影响每单位活 BW 的肝重（29.2 对 28.6）。此外，饮食抗生素增加（P < 0.05）第 14 天的血清三碘甲状腺原氨酸和四碘甲状腺原氨酸水平，而膳食 CM 不影响这些激素的血清水平。膳食抗生素减少（P < 0。05) 在第 20 天，白细胞和中性粒细胞的数量分别减少了 38% 和 43%，而膳食 CM 在第 20 天倾向于减少（P = 0.09）白细胞数量 19%。 CM 饮食倾向于大于抗生素饮食（P < 0.10）。在第 20 天，日粮抗生素降低（P < 0.05）盲肠中单个挥发性脂肪酸的浓度和总挥发性脂肪酸的浓度 61%，而日粮 CM 降低（P < 0.05）盲肠丁酸浓度 61%并且趋向于在第 20 天使总挥发性脂肪酸浓度降低 30% (P < 0.10)。总之，膳食中添加 20% CM 提高了 ADG 并趋于降低白细胞计数。因此，