The public health and medical response to a radiological or nuclear incident requires the capability to sort, assess, treat, triage and ultimately discharge, as well as to refer or transport people to their next step in medical care. The Public Health Emergency Medical Countermeasures Enterprise (PHEMCE), directed by the U.S. Department of Health and Human Services (HHS), facilitates a comprehensive, multi-agency effort to develop and deploy radiation biodosimetry tests. Within HHS, discovery and development of biodosimetry tests includes the National Institute of Allergy and Infectious Diseases (NIAID) National Institutes of Health (NIH), the Office of the Assistant Secretary of Preparedness and Response (ASPR), Biomedical Advanced Research and Development Authority (BARDA), and the Food and Drug Administration (FDA) as primary partners in this endeavor. The study of radiation biodosimetry has advanced significantly, with expansion into the fields of cytogenetics, genomics, proteomics, metabolomics, lipidomics and transcriptomics. In addition, expansion of traditional cytogenetic assessment methods using automated platforms, and development of laboratory surge capacity networks have helped to advance biodefense preparedness. This article describes various programs and coordinating efforts between NIAID, BARDA and FDA in the development of radiation biodosimetry approaches to respond to radiological and nuclear threats.

对放射性或核事件的公共卫生和医疗响应需要分类、评估、治疗、分类和最终出院的能力，以及将人们转介或运送到下一步医疗护理的能力。由美国卫生与公众服务部 (HHS) 指导的公共卫生紧急医疗对策企业 (PHEMCE) 促进了全面的、多机构的努力，以开发和部署辐射生物剂量学测试。在 HHS 内，发现和开发生物剂量测定测试的机构包括美国国家过敏和传染病研究所 (NIAID)、美国国立卫生研究院 (NIH)、准备和应对助理部长办公室 (ASPR)、生物医学高级研究与发展局 (巴尔达), 和食品药品监督管理局 (FDA) 作为这项工作的主要合作伙伴。辐射生物剂量学的研究取得了显着进展，扩展到细胞遗传学、基因组学、蛋白质组学、代谢组学、脂质组学和转录组学领域。此外，使用自动化平台扩展传统的细胞遗传学评估方法，以及实验室浪涌能力网络的发展，都有助于推进生物防御准备工作。本文介绍了 NIAID、BARDA 和 FDA 在开发辐射生物剂量学方法以应对放射和核威胁方面的各种计划和协调工作。使用自动化平台扩展传统的细胞遗传学评估方法，以及实验室激增能力网络的发展有助于推进生物防御准备工作。本文介绍了 NIAID、BARDA 和 FDA 在开发辐射生物剂量学方法以应对放射和核威胁方面的各种计划和协调工作。使用自动化平台扩展传统的细胞遗传学评估方法，以及实验室激增能力网络的发展有助于推进生物防御准备工作。本文介绍了 NIAID、BARDA 和 FDA 在开发辐射生物剂量学方法以应对放射和核威胁方面的各种计划和协调工作。