This study aimed to identify the uncertainty in estimations of organ absorbed dose using dedicated software by comparing with corresponding doses measured in physical phantoms. The comparison was performed for whole-body computed tomography (CT) obtained as part of positron emission tomography. Whole-body CT scans provide an advantage in terms of comparison because all organs are in the primary beam of the irradiated area. Organ doses estimated by the different software programs (CT-Expo, VirtualDose and NCICT) were compared by thermoluminescent detector measurements in anthropomorphic phantoms in 1-y-old, 5-y-old and adult patients. Differences were within ~15% in 12 major organs. However, differences of ~30% were observed in organs located at slightly different positions in the computational models compared to the physical phantoms. All investigated programs were deemed suitable for accurate estimation of organ absorbed dose.

中文翻译：

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不同方法估计的儿童和成人患者模型全身计算机断层扫描中器官吸收剂量的比较

本研究旨在通过与在物理模型中测量的相应剂量进行比较，确定使用专用软件估算器官吸收剂量的不确定性。对作为正电子发射断层扫描的一部分获得的全身计算机断层扫描 (CT) 进行了比较。全身 CT 扫描在比较方面具有优势，因为所有器官都在照射区域的主要光束中。不同软件程序（CT-Expo、VirtualDose 和 NCICT）估计的器官剂量通过热致发光探测器测量在 1 岁、5 岁和成人患者的拟人体模中进行比较。12 个主要器官的差异在 15% 以内。然而，与物理模型相比，在计算模型中位于略微不同位置的器官中观察到了约 30% 的差异。