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Neural and Retinal Characteristics in Relation to Working Memory in Older Adults with Mild Cognitive Impairment
Current Alzheimer Research ( IF 2.1 ) Pub Date : 2021-02-28 , DOI: 10.2174/1567205018666210608114044
Mabel N K Wong 1 , Daniel W L Lai 2 , Henry H-L Chan 3 , Bess Y-H Lam 4
Affiliation  

Objective: This study investigated the relationship between neural activities and retinal structures associated with working memory (WM) in older adults with mild cognitive impairment (MCI).

Methods: Eleven older adults with MCI and 29 healthy controls (60 to 73 years old) were tested. All participants underwent an event-related potential (ERP) recording while performing the two-back memory task. The Optical coherence tomography angiography (OCT-A) was administered to examine the perfusion and vessel density in the retina.

Results: Results showed that WM performance in the MCI group was negatively associated with ERP latencies in central parietal regions (CP6 and CP8) (ps< 0.05). The left nasal vessel and perfusion densities were negatively correlated with the latencies in these two central parietal regions and positively related to WM performance only in the MCI group (ps< 0.05).

Conclusion: The findings on WM, central parietal brain activity, and left nasal vessel and perfusion densities in the retina help us gain a better understanding of the neural and retinal underpinnings of WM in relation to MCI.



中文翻译:

轻度认知障碍老年人工作记忆的神经和视网膜特征

目的:本研究调查了患有轻度认知障碍 (MCI) 的老年人的神经活动与与工作记忆 (WM) 相关的视网膜结构之间的关系。

方法:测试了 11 名患有 MCI 的老年人和 29 名健康对照者(60 至 73 岁)。所有参与者在执行两回记忆任务时都进行了事件相关电位 (ERP) 记录。光学相干断层扫描血管造影 (OCT-A) 用于检查视网膜中的灌注和血管密度。

结果:结果显示 MCI 组的 WM 表现与中央顶叶区域(CP6 和 CP8)的 ERP 潜伏期呈负相关(ps < 0.05)。左鼻血管和灌注密度与这两个中央顶叶区域的潜伏期呈负相关,仅在 MCI 组中与 WM 性能呈正相关(ps < 0.05)。

结论:关于 WM、中央顶叶脑活动、左鼻血管和视网膜灌注密度的发现帮助我们更好地了解 WM 与 MCI 相关的神经和视网膜基础。

更新日期:2021-02-28
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