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A Portable Wireless Urine Detection System With Power-Efficient Electrochemical Readout ASIC and ABTS-CNT Biosensor for UACR Detection
IEEE Transactions on Biomedical Circuits and Systems ( IF 5.1 ) Pub Date : 2021-06-08 , DOI: 10.1109/tbcas.2021.3087475
Shuenn-Yuh Lee , Hao-Yun Lee , Ding-Siang Ciou , Zhan-Xian Liao , Peng-Wei Huang , Yi-Ting Hsieh , Yi-Chieh Wei , Chia-Yu Lin , Meng-Dar Shieh , Ju-Yi Chen

This work presents a portable wireless urine detection system which consists of an electrochemical readout application specific integrated circuit (ASIC) and a biosensor composed of 2, 2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) and carbon nanotube (ABTS-CNT) for the detection of urine albumin-to-creatinine ratio (UACR). The ASIC includes a potentiostat, a digital circuitry and a power management circuit which can perform electrochemistry techniques with a dual-channel screen-printing carbon electrode (SPCE). Electrochemical experiments on the proposed biosensor (SPCE|ABTS-CNT|Nafion) have revealed promising sensing characteristics for creatinine and human serum albumin detection. Practical urine tests has demonstrated the capability of the proposed urine detection system for UACR detection with both the power-efficient readout ASIC and the ABTS-CNT biosensor. A user-friendly prototype has also been designed which can be useful for either personal health administrationor homecare.

中文翻译:

一种便携式无线尿液检测系统,具有用于 UACR 检测的高效电化学读出 ASIC 和 ABTS-CNT 生物传感器

这项工作提出了一种便携式无线尿液检测系统,该系统由电化学读出专用集成电路 (ASIC) 和由 2, 2'-叠氮基-双 (3-乙基苯并噻唑啉-6-磺酸) 和碳纳米管 (ABTS) 组成的生物传感器组成。 -CNT) 用于检测尿白蛋白肌酐比值 (UACR)。ASIC 包括一个恒电位仪、一个数字电路和一个电源管理电路,可以使用双通道丝网印刷碳电极 (SPCE) 执行电化学技术。所提出的生物传感器(SPCE|ABTS-CNT|Nafion)的电化学实验揭示了肌酐和人血清白蛋白检测的有希望的传感特性。实际的尿液测试已经证明了所提出的尿液检测系统的能力,用于 UACR 检测,同时具有节能读出 ASIC 和 ABTS-CNT 生物传感器。还设计了一个用户友好的原型,可用于个人健康管理或家庭护理。
更新日期:2021-08-13
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