The major histocompatibility complex (MHC) loci are amongst the most polymorphic regions in the genomes of vertebrates. In the human population, thousands of MHC gene variants (alleles) exist that translate into distinct allotypes equipped with overlapping but unique peptide binding profiles. Understanding the differential structural and dynamic properties of MHC alleles and their interaction with critical regulators of peptide exchange bears the potential for more personalized strategies of immune modulation in the context of HLA-associated diseases.

中文翻译：

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主要组织相容性复合体 (MHC) I 类和 II 类蛋白质：多态性对抗原呈递的影响。

主要组织相容性复合体 (MHC) 基因座是脊椎动物基因组中多态性最多的区域之一。在人群中，存在数以千计的 MHC 基因变体（等位基因），它们转化为具有重叠但独特的肽结合谱的不同同种异体。了解 MHC 等位基因的不同结构和动态特性以及它们与肽交换的关键调节因子的相互作用，有可能在 HLA 相关疾病的背景下制定更个性化的免疫调节策略。