Hypersensitivity pneumonitis (HP) is a relatively new construct, first reported in the early 20th century, despite major aetiological factors (farming, bird husbandry) having been part of human activities for millennia. Initial confirmed HP reports included exposure to farming and forestry (1932) and bird exposure (1965), much more recently than is often assumed. Later changes in occupational and living practices have led to HP associated with isocyanates, machine coolants, indoor mould, hot tubs and other exposures. Evolution of our pathological understanding of interstitial lung disease in general, wider computed tomography utilisation and advances in immunology and genomics have shaped our modern conceptualisation of HP. Examining historical accounts of HP and its causative factors not only considers when the first cases were recognised, but also explores why the disease emerged at specific times and places, and may provide further insights relevant to the mechanisms underlying HP and disease prevention.

过敏性肺炎 (HP) 是一种相对较新的结构，在 20 世纪初首次报道，尽管几千年来主要病因（农业、鸟类饲养）一直是人类活动的一部分。最初确认的 HP 报告包括接触农业和林业（1932 年）和接触鸟类（1965 年），这比通常假设的要晚得多。后来职业和生活习惯的变化导致 HP 与异氰酸酯、机器冷却剂、室内​​模具、热水浴缸和其他暴露有关。我们对间质性肺病的病理学理解的演变、更广泛的计算机断层扫描应用以及免疫学和基因组学的进步塑造了我们对 HP 的现代概念化。检查 HP 的历史记录及其致病因素不仅要考虑第一个案例是何时被承认的，