Curcuma longa (Turmeric) is a tropical herbaceous perennial plant of the family Zingiberaceae and contains curcuminoids, sesquiterpenoids and monoterpenoids as its major components. Given the broad range of activities that Curcuma longa possesses and also its use as a traditional epilepsy remedy, this review attempts to systematically review the experimentally proven activities of Curcuma longa and its bioactive components, which are related to the management of epileptic seizures. Using the PRISMA model, five databases (Google Scholar, PubMed, ScienceDirect, SCOPUS and SpringerLink) were searched using the keywords [“Curcuma longa” AND “Epilepsy”] and [“Curcuma longa” AND “Seizures”], leaving 34 articles that met the inclusion criteria. The present systematic review elaborated on the experimentally proven potential of Curcuma longa components, such as an aqueous extract of Curcuma longa itself, Curcuma longa oil and active constituents like curcuminoids and bisabolene sesquiterpenoids found in Curcuma longa with anti-seizure potential. Using human equivalent dose calculations, human treatment parameters were suggested for each component by analysing the various studies in this review. This review also determined that the principal components possibly exert their anti-seizure effect via the reduction of corticosterone, modulation of neurotransmitters signalling, modulation of sodium ion channels, reduction of oxidative DNA damage, reduction of lipid peroxidation, upgregulation of brain-derived neurotrophic factor (BDNF) and γ-aminobutyric acid (GABA) mediated inhibition. It is anticipated that this review will help pave the way for future research into the development of Curcuma longa and its neuroactive constituents as potential drug candidates for the management of epilepsy.

姜黄（姜黄）是姜科的热带多年生草本植物，主要​​成分为姜黄素、倍半萜类和单萜类化合物。鉴于姜黄具有广泛的活性以及其作为传统癫痫药物的用途，本综述试图系统地回顾经实验证明的姜黄及其生物活性成分的活性，这些活性与癫痫发作的管理有关。使用 PRISMA 模型，使用关键字 [“Curcuma longa” AND “Epilepsy”] 和 [“Curcuma longa” AND “Seizures”] 搜索了五个数据库（Google Scholar、PubMed、ScienceDirect、SCOPUS 和 SpringerLink），留下 34 篇文章符合纳入标准。本系统综述详细阐述了姜黄成分的实验证明潜力，例如姜黄本身的水提取物、姜黄油和姜黄中的姜黄素和红没药烯倍半萜等活性成分，具有抗癫痫作用。使用人体等效剂量计算，通过分析本综述中的各种研究，建议了每个成分的人体治疗参数。本综述还确定主要成分可能通过减少皮质酮、调节神经递质信号、调节钠离子通道、减少氧化性 DNA 损伤、减少脂质过氧化、上调脑源性神经营养因子发挥其抗癫痫作用。 (BDNF) 和 γ-氨基丁酸 (GABA) 介导的抑制作用。