BACKGROUND Plants that are rich in triterpenoid compounds possess various biological activities and are reported in many scientific works. Triterpenoids, because of their broad sources, wide variety, high medicinal value, and anti-tumor properties, have drawn great attention from scientists. However, the lack of approach to understand the link between their chemical structures and biological activities has limited the fundamental comprehension of these compounds in cancer therapy. OBJECTIVE The aim of the study is to summarize the list of plants with triterpenoids and their derivatives that are a source of potential novel therapeutic anti-cancer agents by interpreting the network of anti-cancer activity and the structures of triterpenoids and their derivatives. METHODS This work focuses on analyzing relevant patents and references that detail the structure of triterpenoids and their derivatives for the treatment of tumors. RESULTS Pentacyclic triterpenoid plays a more important role in improving the autophagic signaling pathways of cancer cells compared to tetracyclic triterpenoid. CONCLUSION The heterogenous skeleton structure of triterpenoids impairs programmed cell death signaling pathways in various cancers.

中文翻译：

---

三萜类化合物的化学结构和生物活性之间的联系。

背景技术富含三萜类化合物的植物具有多种生物活性，并在许多科学著作中得到报道。三萜类化合物因其来源广泛、种类繁多、药用价值高、抗肿瘤等特性而受到科学家们的高度重视。然而，缺乏了解它们的化学结构和生物活性之间联系的方法限制了对这些化合物在癌症治疗中的基本理解。目的 该研究的目的是通过解释抗癌活性网络和三萜类化合物及其衍生物的结构，总结具有三萜类化合物及其衍生物的植物列表，这些植物是潜在的新型治疗性抗癌剂的来源。方法这项工作的重点是分析相关专利和参考文献，这些专利和参考文献详细说明了用于治疗肿瘤的三萜类化合物及其衍生物的结构。结果与四环三萜相比，五环三萜在改善癌细胞自噬信号通路方面的作用更为重要。结论三萜类化合物的异质骨架结构损害了各种癌症中的程序性细胞死亡信号通路。