Background: The possible interaction between genetic and immunological factors in influencing clinical course of multiple sclerosis (MS) has not been studied previously in Indian population. Aim: In this study we evaluated the association of HLA alleles and OCB in affecting clinical course and disability of MS. Methods: Clinical and demographic features of 145 MS patients who had CSF oligoclonal bands (OCB) tested by isoelectric focussing technique were analyzed, disability status estimated, and HLA DRB1 alleles were genotyped. Results: OCBs were positive in 53.8% (78/145) of all MS cases. Patients with CSF OCB had more frequent relapses and an association with HLA DRB1*15. Early disease onset and a high annualized relapse rate was associated with HLA DRB1*03 allele. A relapsing remitting course for MS was seen with HLA DRB1*03 & 15 while a progressive disease was associated with DRB1*01. Presence of both OCB and HLA DRB1*13 was significantly associated with disability in this cohort. Conclusion: The results of our study suggest that an interaction between immunological and genetic factors may influence disease onset, course, and disability in MS.


中文翻译：

---

评估 HLA DRB1 等位基因和寡克隆带在影响多发性硬化症临床过程中的作用——芒格洛尔脱髓鞘疾病登记处的一项研究


背景：遗传和免疫因素之间可能的相互作用在影响多发性硬化症 (MS) 临床过程中的可能的相互作用尚未在印度人群中进行过研究。目的：在这项研究中，我们评估了 HLA 等位基因和 OCB 在影响 MS 临床过程和残疾方面的关联。方法：对 145 例 MS 患者的临床和人口学特征进行分析，这些患者通过等电聚焦技术检测了 CSF 寡克隆带 (OCB)，估计了残疾状态，并对 HLA DRB1 等位基因进行了基因分型。结果：在所有 MS 病例中，53.8% (78/145) 的 OCB 呈阳性。患有 CSF OCB 的患者复发率更高，并且与 HLA DRB1*15 相关。早期疾病发作和高年复发率与 HLA DRB1*03 等位基因相关。HLA DRB1*03 和 15 观察到 MS 的复发缓解过程，而进行性疾病与 DRB1*01 相关。OCB 和 HLA DRB1*13 的存在与该队列中的残疾显着相关。结论：我们的研究结果表明，免疫学和遗传因素之间的相互作用可能会影响 MS 的疾病发作、病程和残疾。