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Circadian NAD(P)(H) cycles in cell metabolism
Seminars in Cell & Developmental Biology ( IF 7.3 ) Pub Date : 2021-07-17 , DOI: 10.1016/j.semcdb.2021.07.008
Daniel C Levine 1 , Kathryn M Ramsey 1 , Joseph Bass 1
Affiliation  

Intrinsic circadian clocks are present in all forms of photosensitive life, enabling daily anticipation of the light/dark cycle and separation of energy storage and utilization cycles on a 24-h timescale. The core mechanism underlying circadian rhythmicity involves a cell-autonomous transcription/translation feedback loop that in turn drives rhythmic organismal physiology. In mammals, genetic studies have established that the core clock plays an essential role in maintaining metabolic health through actions within both brain pacemaker neurons and peripheral tissues and that disruption of the clock contributes to disease. Peripheral clocks, in turn, can be entrained by metabolic cues. In this review, we focus on the role of the nucleotide NAD(P)(H) and NAD+-dependent sirtuin deacetylases as integrators of circadian and metabolic cycles, as well as the implications for this interrelationship in healthful aging.



中文翻译:

细胞代谢中的昼夜节律 NAD(P)(H) 循环

内在生物钟存在于所有形式的光敏生命中,能够每天预测光/暗周期以及在 24 小时时间尺度上分离能量存储和利用周期。昼夜节律的核心机制涉及细胞自主转录/翻译反馈回路,进而驱动节律性有机体生理学。在哺乳动物中,遗传学研究已经证实,核心生物钟通过大脑起搏器神经元和外周组织的活动在维持代谢健康方面发挥着重要作用,生物钟的破坏会导致疾病。反过来,外围时钟可以被代谢信号所控制。在这篇综述中,我们关注核苷酸 NAD(P)(H) 和 NAD +的作用依赖性去乙酰化酶作为昼夜节律和代谢周期的整合者,以及这种相互关系在健康衰老中的意义。

更新日期:2021-07-17
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