Intestinal mucositis is a common side effect of the chemotherapeutic agent doxorubicin, which is characterized by severe Toll-like receptor (TLR) 2-mediated inflammation. The dietary fiber pectin is shown to prevent this intestinal inflammation through direct inhibition of TLR2 in a microbiota-independent manner. Recent in vitro studies show that inhibition of TLR2 is determined by the number and distribution of methyl-esters of pectins. Therefore, it is hypothesized that the degree of methyl-esterification (DM) and the degree of blockiness (DB) of pectins determine attenuating efficacy on doxorubicin-induced intestinal mucositis.

中文翻译：

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果胶对阿霉素引起的小肠粘膜炎的减轻取决于果胶的甲酯数量和分布

肠道黏膜炎是化疗药物阿霉素的常见副作用，其特征是严重的 Toll 样受体 (TLR) 2 介导的炎症。膳食纤维果胶显示通过以不依赖微生物群的方式直接抑制 TLR2 来预防这种肠道炎症。最近的体外研究表明，TLR2 的抑制取决于果胶甲酯的数量和分布。因此，假设果胶的甲基酯化程度（DM）和阻塞程度（DB）决定了对阿霉素诱导的肠粘膜炎的减弱功效。