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A Novel Pseudo-Three-Component Synthetic Strategy for the Synthesis of 1,6-Dihydroazaazulenes via Cyclization of Pyrrolyl-enones
Synlett ( IF 2 ) Pub Date : 2021-06-24 , DOI: 10.1055/a-1535-6085
Carlos Jesus Cortés-Garcia 1 , Luis Chacón-García 1 , Josue Valentin-Escalera 1 , Ana Karen García-Dueñas 1 , Cesar Rogelio Solorio-Alvarado 2 , Claudia Contreras-Celedón
Affiliation  

A synthetic novel strategy involving a pseudo-three-component reaction to obtain 1,6-dihydroazaazulenes derivates via cyclization of pyrrolyl-enones was developed. This reaction is carried out under mild conditions from simple starting materials and catalyzed with ionic liquid. Notably, three new C–C bonds are formed in the one-pot process. The target molecules are of interest in medicinal chemistry as they contain a privileged scaffold and are considered indole homologues.

中文翻译:

一种通过吡咯基烯酮环化合成 1,6-二氢氮杂芘烯的新型伪三​​组分合成策略

开发了一种合成新策略,该策略涉及伪三组分反应,通过吡咯基烯酮的环化获得 1,6-二氢氮杂氮杂环烯衍生物。该反应由简单的起始原料在温和条件下进行,并在离子液体的催化下进行。值得注意的是,在一锅法中形成了三个新的 C-C 键。目标分子在药物化学中很受关注,因为它们包含一个特殊的支架并被认为是吲哚同系物。
更新日期:2021-07-16
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