The hypothesis that the physiologic response to psychologic stress influences the initiation of cancer is highly controversial. The link between initiating stressors, the psychologic stress response, and disease is plausible, considering that the stress response is associated with defined physiologic outcomes and molecular mechanisms. In light of this, we review the clinical relevance of psychologic stress on the risk of cancer, and we propose potential molecular pathways that may link the stress response to early stages of malignant cell transformation.

中文翻译：

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心理压力在癌症发生中的作用：临床相关性和潜在的分子机制

对心理压力的生理反应影响癌症发生的假设存在很大争议。考虑到应激反应与确定的生理结果和分子机制相关，起始应激源、心理应激反应和疾病之间的联系是合理的。有鉴于此，我们回顾了心理压力与癌症风险的临床相关性，并提出了可能将压力反应与恶性细胞转化早期阶段联系起来的潜在分子途径。