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Renal Revascularization Attenuates Myocardial Mitochondrial Damage and Improves Diastolic Function in Pigs with Metabolic Syndrome and Renovascular Hypertension
Journal of Cardiovascular Translational Research ( IF 3.4 ) Pub Date : 2021-07-16 , DOI: 10.1007/s12265-021-10155-3
Rahele A Farahani 1 , Shasha Yu 1 , Christopher M Ferguson 1 , Xiang-Yang Zhu 1 , Hui Tang 1 , Kyra L Jordan 1 , Ishran M Saadiq 1 , Sandra M Herrmann 1 , Alejandro R Chade 2 , Amir Lerman 3 , Lilach O Lerman 1, 3 , Alfonso Eirin 1
Affiliation  

Percutaneous transluminal renal angioplasty (PTRA) may improve cardiac function in renovascular hypertension (RVH), but its effect on the biological mechanisms implicated in cardiac damage remains unknown. We hypothesized that restoration of kidney function by PTRA ameliorates myocardial mitochondrial damage and preserves cardiac function in pigs with metabolic syndrome (MetS) and RVH. Pigs were studied after 16 weeks of MetS+RVH, MetS+RVH treated 4 weeks earlier with PTRA, and Lean and MetS Sham controls (n=6 each). Cardiac function was assessed by multi-detector CT, whereas cardiac mitochondrial morphology and function, microvascular remodeling, and injury pathways were assessed ex vivo. PTRA attenuated myocardial mitochondrial damage, improved capillary and microvascular maturity, and ameliorated oxidative stress and fibrosis, in association with attenuation of left ventricular remodeling and diastolic dysfunction. Myocardial mitochondrial damage correlated with myocardial injury and renal dysfunction. Preservation of myocardial mitochondria with PTRA can enhance cardiac recovery, underscoring its therapeutic potential in experimental MetS+RVH.



中文翻译:

肾血运重建可减轻代谢综合征和肾血管性高血压猪的心肌线粒体损伤并改善舒张功能

经皮腔内肾血管成形术 (PTRA) 可改善肾血管性高血压 (RVH) 患者的心脏功能,但其对涉及心脏损伤的生物学机制的影响仍不清楚。我们假设 PTRA 恢复肾功能可改善代谢综合征 (MetS) 和 RVH 猪的心肌线粒体损伤并保持心脏功能。MetS+RVH 治疗 16 周后对猪进行研究,MetS+RVH 治疗 4 周前用 PTRA 和 Lean 和 MetS Sham 对照(n= 6 个)。通过多探测器 CT 评估心脏功能,而离体评估心脏线粒体形态和功能、微血管重塑和损伤途径。PTRA 减轻心肌线粒体损伤,改善毛细血管和微血管成熟度,改善氧化应激和纤维化,与左心室重塑和舒张功能障碍的减弱有关。心肌线粒体损伤与心肌损伤和肾功能障碍相关。用 PTRA 保存心肌线粒体可以增强心脏恢复,强调其在实验性 MetS+RVH 中的治疗潜力。

更新日期:2021-07-16
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