The coronavirus-2019 (COVID-19) pandemic has presented many new challenges to the healthcare community with the sheer number of individuals affected and the range of symptoms at presentation. Early findings have shown that increased age is an independent risk factor for COVID-19 severity. Diabetes and hypertension were also found to be strong independent risk factors for severe COVID-19. It was later discovered that obesity is a strong risk factor for severe disease as well. Possible mechanisms for the increased risk associated with metabolic disease include increased prevalence of acute respiratory syndrome, immune cell dysfunction, and chronic inflammatory states associated with obesity and diabetes. Acknowledging these risk factors has consequences for addressing vaccination strategies as well as healthcare disparities.

中文翻译：

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2019 年冠状病毒病严重程度增加的代谢风险因素综述。

2019 冠状病毒 (COVID-19) 大流行给医疗保健界带来了许多新的挑战，受影响的人数之多以及出现的症状范围之广。早期研究结果表明，年龄增长是 COVID-19 严重程度的独立危险因素。糖尿病和高血压也被发现是重症 COVID-19 的重要独立危险因素。后来发现，肥胖也是严重疾病的一个重要危险因素。与代谢疾病相关的风险增加的可能机制包括急性呼吸综合征、免疫细胞功能障碍以及与肥胖和糖尿病相关的慢性炎症状态的患病率增加。承认这些风险因素对于解决疫苗接种策略以及医疗保健差异具有重要意义。