Dynamic constitutional chemistry is an extremely powerful tool to control the activity of Carbonic Anhydrase (CA) in the presence of dynamic libraries. These adaptive systems operate within the inner CA active site or on the outer enzyme microenvironment used to overexpress specific dynamic frameworks that lead to the regulation of CA activity. This review describes incipient examples toward the generation of chemical diversity and their functional amplification toward effective strategies for CA inhibition and activation.

中文翻译：

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碳酸酐酶的组成动态抑制/活化

动态组成化学是在存在动态库的情况下控制碳酸酐酶 (CA) 活性的极其强大的工具。这些适应性系统在内部 CA 活性位点内或在用于过度表达导致 CA 活性调节的特定动态框架的外部酶微环境中运行。这篇综述描述了产生化学多样性的早期例子，以及它们对 CA 抑制和激活的有效策略的功能放大。